1801-38-3Relevant academic research and scientific papers
Ozonide compounds with inhibitory activity for urokinase production and angiogenesis
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, (2008/06/13)
The invention provides a urokinase production inhibitor or angiogenesis inhibitor comprising as an active component an ozonide derivative represented by the formula (1), and method of prevention or therapy using the inhibitor wherein A is an oxygen atom o
Chemical transformations of solvent-derived ozonolysis products: Improved synthesis of polycyclic 1,2,4,6-tetroxepanes from α-alkoxy α′-hydroperoxy cyclic ethers and aldehydes
McCullough, Kevin J.,Ushigoe, Yoshihiro,Tanaka, Shogo,Masuyama, Araki,Nojima, Masatomo
, p. 3053 - 3057 (2007/10/03)
α-Alkoxy α′-hydroperoxy cyclic ethers condense with aliphatic aldehydes under acidic conditions to produce the bicyclic 1,2,4,6-tetroxepanes. By X-ray crystallographic analysis, the tetroxepanes 5b and 12b, derived from cyclocondensation of the hydroperoxides 4 and 8 respectively with acetaldehyde, were shown to be exo-isomers.
Cycloaddition between Carbonyl Oxides and Dicarbonyl Compounds: Isolation and Characterization of Novel Polycyclic 1,2,4,6-Tetroxepane Derivatives
McCullough, Kevin J.,Sugimoto, Toshiya,Tanaka, Shogo,Kusabayashi, Shigekazu,Nojima, Masatomo
, p. 643 - 652 (2007/10/02)
Formaldehyde O-oxide reacts with dicarbonyl compounds to produce mono-ozonides formed by conventional cycloadditions to an aldehyde carbonyl group of the substrate, and/or polycyclic 1,2,4,6-tetroxepane derivatives arising from formal cycloadditions involving both carbonyl groups.Similar reactions between the more highly substituted carbonyl oxides, benzaldehyde and octanal O-oxides, and dicarbonyl compounds yielded the corresponding mono-ozonides as the sole isolable cycloaddition products.In certain favorable cases, mono-ozonides could undergo acid-catalysed intramolecular rearrangement to the corresponding 1,2,4,6-tetroxepanes.X-Ray crystallographic analyses of two 1,2,4,6-tetroxepanes, 6a and 13b, are recorded.
Ozonolyses of 1,2-Diphenyl- and 2-Phenylindene
Sugimoto, Toshiya,Teshima, Koichi,Nakamura, Norinaga,Nojima, Masatomo,Kusabayashi, Shigekazu,McCullough, Kevin J.
, p. 135 - 141 (2007/10/02)
Ozonolyses of 1,2-diphenylindene (7), 2-phenylindene (18), and the structurally related acyclic keto olefins 13, 14, 26, and 32 were conducted in MeOH/CH2Cl2 at -70 and 0 deg C.The structure of the indenes, 7 and 18, and the rection temperature, were foun
