180137-65-9Relevant academic research and scientific papers
Synthesis and antiviral activity of new 1, 3, 4-dithi(thiadi)azino[4, 5-a]benzimidazole derivatives involving oxidative N-S and N-N bond formations
Yadav,Pal, Daya Ram
, p. 748 - 751 (2007/10/03)
Benzimidazol-2-ylalkyl N-aryldithiocarbamates (3a-d) undergo oxidative and chemoselective heterocyclizations with I2 and SOCl2 to yield 2-arylimino-4-methyl/H-2H, 4H[1, 3, 4]dithiazino[4, 5-a]benzimidazoles (4a-d) and 1-aryl-4-methyl/H-1, 2-dihydro-4H-[1, 3, 4]thiadiazino[4, 5-a]benzimidazol-2-thiones(5a-d), respectively. Compounds 5a-d on dethioxygenation furnish 1-aryl-4-methyl/H-1, 2-dihydro-4H-[1, 3, 4]thiadiazino[4, 5-a]benzimidazol-2-ones (6a-d). Amongst the compounds 3-6, compounds 5b, 5d and 6d exhibited 72-75% in vitro disease control against Corn virus, Bean virus and Cucumber mosaic virus at 1000 ppm concentration.
