19275-82-2

Usage

Uses

Used in Organic Synthesis:
1H-Benzimidazole,2-(1-chloroethyl)-(9CI) is used as a building block for the synthesis of complex organic molecules. Its unique structure allows for the creation of a wide range of compounds with diverse properties and potential applications.
Used in Pharmaceutical Research:
1H-Benzimidazole,2-(1-chloroethyl)-(9CI) is used as a precursor in the production of certain pharmaceutical drugs. Its chemical properties make it a valuable component in the development of new medications with potential therapeutic benefits.
Used in Materials Science:
1H-Benzimidazole,2-(1-chloroethyl)-(9CI) may have potential applications in the field of materials science. Its unique structure could contribute to the development of new materials with specific properties for various industries.
Used in Chemical Engineering:
1H-Benzimidazole,2-(1-chloroethyl)-(9CI) may also have potential applications in chemical engineering. Its properties could be utilized in the design and optimization of chemical processes and reactions.
It is important to handle and use 1H-Benzimidazole,2-(1-chloroethyl)-(9CI) with caution, as it may have potential hazards and risks associated with its use. Proper safety measures should be taken to minimize any risks during its application in various industries.

Upstream product

• 95-54-5 1,2-diamino-benzene 
• 598-78-7 (R,S)-2-chloropropionic acid 
• 16414-04-3 1-benzimidazol-2-ylethanol 
• 7647-01-0 hydrogenchloride 

Downstream Products

• 180137-57-9 (4-chloro-phenyl)-dithiocarbamic acid 1-(1H-benzoimidazol-2-yl)-ethyl ester 
• 952424-77-0 2-(1-benzenesulfonyl-ethyl)-1H-benzimdazole 
• 952424-87-2 2-(1-chloroethyl)-1-benzyl-benzimidazole 
• 952424-76-9 2-[1-(toluene-4-sulfonyl)-ethyl]-1H-benzimidazole 
• 58282-03-4 1-methyl-2-(α-chloroethyl)benzimidazole 
• 3176-70-3 2-(1-mercaptoethyl)benzimidazole 
• 153430-86-5 1-Methyl-4-phenyl-1H-2-thia-4,4a,9-triaza-fluorene-3-thione 
• 180137-65-9 4-(4-chloro-phenyl)-1-methyl-1H-2-thia-4,4a,9-triaza-fluorene-3-thione 
• 103153-63-5 4-[1-(1H-benzimidazol-2-yl)-ethylamino]-benzoic acid ethyl ester 
• 95943-57-0 N-{4-[(Ξ)-1-(1H-benzimidazol-2-yl)-ethylamino]-benzoyl}-L-glutamic acid diethyl ester 

Relevant academic research and scientific papers

Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives

Benzimidazole and piperazines are the important pharmacophores in the structures of many antifungal compounds. Further, the phenylmethanone are also a unique class of compounds whose antifungal profile is not much exploited. So to exploit their antifungal potential we have selected these three combinations and framed the novel parent structure for our research work. In this study a novel series of benzimidazoles derivatives was synthesized by microwave irradiation and characterized by 1H NMR, 13C NMR, Infra Red (IR), and Mass Spectroscopy (MS), and by elemental analysis. The screening of compound for in vitro (turbidimetric method) antifungal activity against C.albicans revealed activity in many of the compounds as comparable to that of ketoconazole.

Synthesis of novel 2-[1-(1H-benzimidazol-2-yl)-ethylsulfanyl]-3H- quinazolin-4-ones

Condensation of 2-(4-oxo-3,4-dihydroquinazolin-2-ylsulfanyl)-propionic acid (1) with o-phenylenediamine (2) gave 2-[1-(1H-benzimidazol-2-yl)-ethylsulfanyl] -3H-quinazolin-4-one (3). The latter can also be prepared by the reaction of 2-(1-chloroethyl)-1H-benzimidazole (4) with 2-mercapto-3W-quinazolin-4-one (5) either in acetone/ triethylamine or in DMF / K2CO3 in the presence of TBAB as phase transfer catalyst. 3 can also be prepared yet by an alternative method involving reaction of 4 with potassium ethylthioxanthate yielding dithiocarbonic acid S-[1 H-benzomidazol-2-yl) ethyl) ethyl ester (6) and subsequent condensation of the latter with o-aminobenzamide (7), in the presence of TFA, under reflux in toluene.

Bicyclic Benzimidazole Compounds and Their Use as Metabotropic Glutamate Receptor Potentiators

Compounds of Formula I: wherein A, B, D, L, R1, R2, R3, R4, m, and n are as defined for Formula I in the description. The invention also relates to processes for the preparation of the compounds and to new intermediates employed in the preparation, pharmaceutical compositions containing the compounds, and to the use of the compounds in therapy.

Studies on synthesis of unsymmetrical 2,2′-bisbenzimidazole sulphides of pharmacological interest

Condensation of 2-(α-chloroethyl)benzimidazole 1 with benzimidazole-2-thiol 2 gives 2-(α-thioethyl-2′-benzimidazolyl)- benzimidazole 3. The latter can also be prepared by the reaction of 2-(α-thioethyl)benzimidazoie 4 with 2-chlorobenzimidazole 5. Alternatively, 3 can also be synthesized by the independent condensation of o-phenylenediamine 7 respectively with 2-(s-α-ethyl-o-ethyldithio- carbonate)benzimidazole 6 and with 2-(α-thiopropionic acid) benzimidazole 8. The structures of all the compounds synthesized have been established on the basis of their spectroscopic data.

COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR

Compounds active on protein kinases are described, as well as methods of using such compounds to treat diseases and conditions associated with aberrant activity of protein kinases.

Synthesis and antiviral activity of new 1, 3, 4-dithi(thiadi)azino[4, 5-a]benzimidazole derivatives involving oxidative N-S and N-N bond formations

Benzimidazol-2-ylalkyl N-aryldithiocarbamates (3a-d) undergo oxidative and chemoselective heterocyclizations with I2 and SOCl2 to yield 2-arylimino-4-methyl/H-2H, 4H[1, 3, 4]dithiazino[4, 5-a]benzimidazoles (4a-d) and 1-aryl-4-methyl/H-1, 2-dihydro-4H-[1, 3, 4]thiadiazino[4, 5-a]benzimidazol-2-thiones(5a-d), respectively. Compounds 5a-d on dethioxygenation furnish 1-aryl-4-methyl/H-1, 2-dihydro-4H-[1, 3, 4]thiadiazino[4, 5-a]benzimidazol-2-ones (6a-d). Amongst the compounds 3-6, compounds 5b, 5d and 6d exhibited 72-75% in vitro disease control against Corn virus, Bean virus and Cucumber mosaic virus at 1000 ppm concentration.