180144-29-0Relevant academic research and scientific papers
Substituted 4-phenylthiazole derivatives, process for their preparation and pharmaceutical compositions containing them
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, (2008/06/13)
The invention concerns compounds of formula STR1 in which R, A, R1 and Y are as defined in claim 1. The instant compounds have an affinity for the fibrinogen receptor: the complex of the glycoproteins IIb/llIa (GP IIb/IIIa); more particularly,
New Orally Active Non-Peptide Fibrinogen Receptor (GpIIb-IIIa) Antagonists: Identification of Ethyl 3-[7V-[4-[4-[Amino[(ethoxycarbonyl)imino]niethyl]phenyl]l,3-thiazol-2-yl]-V-[l- [(ethoxycarbonyl)methyl]piperid-4-yl]amino]propionate (SR 121787) as a Pote
Badorc, Alain,Bordes, Marie-Fran?oise,De Cointet, Paul,Savi, Pierre,Bernat, André,Laie, Alain,Petitou, Maurice,Maffrand, Jean-Pierre,Herbert, Jean-Marc
, p. 3393 - 3401 (2007/10/03)
The platelet fibrinogen receptor GpIIb-IIIa is curently considered a target of choice for drugs used in the prevention and treatment of thrombosis. Ethyl 3-[2V-[4-[4-[amino[(ethoxycarbonyl)imino]methyl]phenyl]-l,3-thiazol-2-yl]-V-[l- [(ethoxycarbonyl)meth
