18015-03-7

Basic information

• Product Name: 4-{[(E)-thiophen-2-ylmethylidene]amino}benzoic acid
• Synonyms: 4-[(2-thienylmethylidene)amino]benzoic acid
• CAS NO: 18015-03-7
• Molecular Formula: C₁₂H₉NO₂S
• Molecular Weight: 231.2704
• Mol File: 18015-03-7.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 437.8°C at 760 mmHg
• Flash Point: 218.6°C
• Density: 1.26g/cm³
• Vapor Pressure: 1.94E-08mmHg at 25°C
• Refractive Index: 1.634
• CAS DataBase Reference: 4-{[(E)-thiophen-2-ylmethylidene]amino}benzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-{[(E)-thiophen-2-ylmethylidene]amino}benzoic acid(18015-03-7)
• EPA Substance Registry System: 4-{[(E)-thiophen-2-ylmethylidene]amino}benzoic acid(18015-03-7)

Safety Data

• Hazardous Substances Data: 18015-03-7(Hazardous Substances Data)

Upstream product

• 98-03-3 thiophene-2-carbaldehyde 
• 150-13-0 4-amino-benzoic acid 

Relevant articles and documents

Mechanochemistry in action: Exploitation of internal acid catalysis in Solvent-free synthesis of imines and evaluation of radical scavenging activities of imino derivatives

Mechanochemical protocol has been exploited to accomplish the synthesis of imino derivatives from aromatic amines with acidic functionalities and different aromatic aldehydes in excellent to nearly quantitative yields. Presence of acidic groups in the aromatic amines has been found to have profound influence on the course of the reaction. The prepared imines were screened for in vitro antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Some of the prepared imino derivatives displayed good to moderate antioxidant property when compared with standard natural antioxidant (L-ascorbic acid).

Hydrolysis of Heterocyclic Schiff Bases in Neutral Aqueous Solution

Eighteen heterocyclic schiff bases derived from furan-2-, thiophene-2, thiophene-3- and pyrrole-2-carboxyaldehydes have been hydrolysed in neutral aq. solutions.A correlation between kobs and the structure has been established.