18015-03-7Relevant academic research and scientific papers
Mechanochemistry in action: Exploitation of internal acid catalysis in Solvent-free synthesis of imines and evaluation of radical scavenging activities of imino derivatives
Sarma, Madhushree Das,Ghosh, Subhojit
, p. 345 - 349 (2021/02/02)
Mechanochemical protocol has been exploited to accomplish the synthesis of imino derivatives from aromatic amines with acidic functionalities and different aromatic aldehydes in excellent to nearly quantitative yields. Presence of acidic groups in the aromatic amines has been found to have profound influence on the course of the reaction. The prepared imines were screened for in vitro antioxidant activity using 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical. Some of the prepared imino derivatives displayed good to moderate antioxidant property when compared with standard natural antioxidant (L-ascorbic acid).
The synthesis of novel methotrexate-like compounds
Colak, Naki,Yildirir, Yilmaz,Kavutcu, Mustafa,Nurlu, Nilhan
, p. 1283 - 1287 (2008/03/27)
Methotrexate (MTX) is a folate antagonist used in treatment of several chronic inflammatory and neoplastic conditions. In this study, new MTX-like compounds that may-be potential anticancer agents were synthesized and their structures were determined by IR, UV, GC-MS, 1H NMR, and 13C NMR spectra. Also, in this study, a series structurally related to MTX or folate analogous compounds were evaluated whether they have inhibitory properties on the dihydrofolate reductase activity (DHFR).
Hydrolysis of Heterocyclic Schiff Bases in Neutral Aqueous Solution
Saeed, Ali A. H.
, p. 92 - 93 (2007/10/02)
Eighteen heterocyclic schiff bases derived from furan-2-, thiophene-2, thiophene-3- and pyrrole-2-carboxyaldehydes have been hydrolysed in neutral aq. solutions.A correlation between kobs and the structure has been established.
