180160-93-4

Basic information

• Product Name: 6-chloro-3H-spiro[isobenzofuran-1,4'-piperidine]
• Synonyms: 6-chloro-3H-spiro[isobenzofuran-1,4'-piperidine];5-Chloro-1,3-dihydrospiro[isobenzofuran-3,4'-piperidine];Spiro[isobenzofuran-1(3H),4'-piperidine], 6-chloro-;5-chlorospiro[1H-2-benzofuran-3,4'-piperidine]
• CAS NO: 180160-93-4
• Molecular Formula: C₁₂H₁₄ClNO
• Molecular Weight: 223.69866
• Mol File: 180160-93-4.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 351.499 °C at 760 mmHg
• Flash Point: 166.381 °C
• Appearance: /
• Density: 1.26
• CAS DataBase Reference: 6-chloro-3H-spiro[isobenzofuran-1,4'-piperidine](CAS DataBase Reference)
• NIST Chemistry Reference: 6-chloro-3H-spiro[isobenzofuran-1,4'-piperidine](180160-93-4)
• EPA Substance Registry System: 6-chloro-3H-spiro[isobenzofuran-1,4'-piperidine](180160-93-4)

Safety Data

• Hazardous Substances Data: 180160-93-4(Hazardous Substances Data)

Usage

General Description

6-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine] is a chemical compound with the molecular formula C16H17ClN2O. It is a spiro amine derivative, which means it contains a spiro carbon atom, and is composed of a piperidine ring system fused to an isobenzofuran moiety. 6-Chloro-3H-spiro[isobenzofuran-1,4'-piperidine] is a potential therapeutic agent and has been studied for its potential use in the treatment of various medical conditions. Its spiro structure makes it a unique and valuable compound in pharmaceutical research, and its synthesis and properties are of interest to medicinal chemists and organic chemists. The specific biological and chemical properties of this compound are still being explored and may have potential applications in drug development and related fields.

Upstream product

• 936-08-3 2-bromo-4-chlorobenzoic acid 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 54595-72-1 1'-benzyl-6-chloro-spiro[isobenzofuran-1,4'-piperidin]-3-one 
• 644968-57-0 1'-benzyl-6-chloro-3H-spiro[2-benzofuran-1,4'-piperidine] 

Relevant articles and documents

INDOL-3-YL-CARBONYL-SPIRO-PIPERIDINE DERIVATIVES AS V1A RECEPTOR ANTAGONISTS

The invention relates to indol-3-yl-carbonyl-spiro-piperidine derivatives which act as V1a receptor antagonists and which are represented by Formula I: wherein the spiro-piperidine head group A and the residues R1, R2 and R3 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, methods for preparing the compounds and pharmaceutical compositions, and their use in the treatment of dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephrotic syndrome, obsessive compulsive disorder, anxious and depressive disorders.

SPIROCYCLIC PIPERIDINES AS MCH1 ANTAGONISTS AND USES THEREOF

This invention is directed to compounds which are selective antagonists for melanin concentrating hormone-1 (MCH1) receptors. The invention provides a pharmaceutical composition comprising a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention provides a pharmaceutical composition made by combining a therapeutically effective amount of the compound of this invention and a pharmaceutically acceptable carrier. This invention further provides a process for making a pharmaceutical composition comprising combining a therapeutically effective amount of the compound of the invention and a pharmaceutically acceptable carrier. This invention also provides a method of reducing the body mass of a subject which comprises administering to the subject an amount of a compound of the invention effective to reduce the body mass of the subject. This invention further provides a method of treating a subject suffering from depression and/or anxiety which comprises administering to the subject an amount of a compound of the invention effective to treat the subject=s depression and/or anxiety. This invention further provides a method of treating a subject suffering from a urinary disorder.