1801697-86-8Relevant articles and documents
Discovery of cyclic guanidines as potent, orally active, human glucagon receptor antagonists
Sinz, Christopher,Chang, Jiang,Lins, Ashley Rouse,Brady, Ed,Candelore, Mari,Dallas-Yang, Qing,Ding, Victor,Jiang, Guoqiang,Lin, Zhen,Mock, Steven,Qureshi, Sajjad,Salituro, Gino,Saperstein, Richard,Shang, Jackie,Szalkowski, Deborah,Tota, Laurie,Vincent, Stella,Wright, Michael,Xu, Shiyao,Yang, Xiaodong,Zhang, Bei,Tata, James,Kim, Ronald,Parmee, Emma
, p. 7131 - 7136 (2015/05/06)
In the course of the development of an aminobenzimidazole class of human glucagon receptor (hGCGR) antagonists, a novel class of cyclic guanidine hGCGR antagonists was discovered. Rapid N-dealkylation resulted in poor pharmacokinetic profiles for the benc