180193-72-0

Usage

Uses

Used in Pharmaceutical Industry:
Phosphonic acid, [3-[bis(phenylmethyl)amino]-2-oxo-4-phenylbutyl]-, dimethyl ester, (S)is used as a pharmaceutical intermediate for the synthesis of bioactive molecules. Its chiral nature and complex substituent make it a valuable building block in the development of new drugs with potential therapeutic applications.
Used in Medicinal Chemistry Research:
Phosphonic acid, [3-[bis(phenylmethyl)amino]-2-oxo-4-phenylbutyl]-, dimethyl ester, (S)is used in medicinal chemistry research to explore its pharmacological properties and potential therapeutic applications. Phosphonic acid, [3-[bis(phenylmethyl)amino]-2-oxo-4-phenylbutyl]-,
dimethyl ester, (S)-'s unique structure and chirality offer opportunities for the discovery of new drug candidates and the optimization of existing ones.

Upstream product

• 63-91-2 L-phenylalanine 
• 111138-83-1 N,N-dibenzyl-L-phenylalanine benzyl ester 
• 756-79-6 dimethyl methane phosphonate 

Downstream Products

• 180193-77-5 (2R,5S)-5-Dibenzylamino-4-oxo-2,6-diphenyl-hexanoic acid butyl ester 
• 180193-80-0 (2R,4S,5S)-5-Dibenzylamino-4-hydroxy-2,6-diphenyl-hexanoic acid butyl ester 
• 198635-29-9 (E)-(S)-4-Dibenzylamino-1-(4-methoxy-phenyl)-5-phenyl-pent-1-en-3-one 
• 198635-31-3 (E)-(S)-4-Dibenzylamino-1,5-diphenyl-pent-1-en-3-one 
• 198635-30-2 (E)-(S)-4-Dibenzylamino-1-naphthalen-1-yl-5-phenyl-pent-1-en-3-one 
• 198635-28-8 4-((E)-(S)-4-Dibenzylamino-3-oxo-5-phenyl-pent-1-enyl)-benzaldehyde 
• 750638-95-0 (E)-(S)-5-Dibenzylamino-4-oxo-6-phenyl-hex-2-enoic acid butyl ester 

Relevant academic research and scientific papers

Diastereoselective reduction of β-ketophosphonates derived from amino acids. A new entry to enantiopure β-hydroxy-γ-aminophosphonate derivatives

The reduction of γ-N,N-dibenzylamino-β-ketophosphonates 4 derived from readily available (S)-tribenzylated amino acids was achieved with catecholborane at -20°C affording γ-amino-β-hydroxyphosphonates 5 in high diastereoselectivity and good chemical yield. These reactions provide a new entry to enantiomerically pure γ-amino-β-hydroxyphosphonates.

Stereoselective synthesis of β-amino alcohols: Diastereoselective reduction of chiral α-amino enones derived from amino acids

α-Amino acids are doubly benzylated at nitrogen to give N,N-dibenzyl amino acids, which can readily be converted to α'-amino enones 3. The α'-amino enones are very resistant to racemization, and undergo highly diastereoselective reduction to afford chiral amino alcohols upon treatment with L-Selectride under non-chelation control.

Remote asymmetric induction in organocopper conjugate additions to 3-ketoacrylates

Remote asymmetric induction has been achieved in the conjugate addition of organocopper reagents to a novel 3-ketoacrylate system, 1. Conjugate additions proceed in moderate to good yield and with high regio-and stereoselectivity in the presence of diethylaluminum chloride. Copyright