180205-34-9

Basic information

• Product Name: Cyclobutanemethanol,1-amino-(9CI)
• Synonyms: Cyclobutanemethanol,1-amino-(9CI);(1-aMinocyclobutyl)Methanol;CyclobutaneMethanol, 1-aMino-;1-Amino-1-hydroxymethylcyclobutane;(1-Aminocyclobutyl)
• CAS NO: 180205-34-9
• Molecular Formula: C₅H₁₁NO
• Molecular Weight: 101.148
• Product Categories: VARIOUSAMINE
• Mol File: 180205-34-9.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 167℃
• Flash Point: 55℃
• Appearance: /
• Density: 1.058
• Storage Temp.: 2-8°C(protect from light)
• PKA: 15.05±0.10(Predicted)
• CAS DataBase Reference: Cyclobutanemethanol,1-amino-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Cyclobutanemethanol,1-amino-(9CI)(180205-34-9)
• EPA Substance Registry System: Cyclobutanemethanol,1-amino-(9CI)(180205-34-9)

Safety Data

• Hazardous Substances Data: 180205-34-9(Hazardous Substances Data)

Usage

General Description

Cyclobutanemethanol,1-amino-(9CI) is a chemical compound with the molecular formula C5H11NO. It is a colorless liquid with a faint odor, and it is insoluble in water but soluble in alcohol and ether. It is used primarily as a chemical intermediate in the production of various pharmaceuticals, including antiparasitic and antiviral drugs. It is also used as a solvent and in the synthesis of other organic compounds. It is important to handle this chemical with care, as it can be harmful if swallowed, inhaled, or in contact with skin, and it may cause irritation to the respiratory system and skin. Additionally, it may have adverse effects on the liver and kidneys. Proper safety precautions and handling procedures should be followed when using this chemical.

Upstream product

• 70780-84-6 1-aminocyclobutane-1-carbonitrile 
• 22264-50-2 1-aminocyclobutane-1-carboxylic acid 
• 215597-35-6 methyl 1-aminocyclobutanecarboxylate 

Downstream Products

• 1423719-33-8 C₅H₁₁NO*C₇H₈O₃S 
• 1401164-09-7 {1-[({2-[4-(trifluoromethyl)phenyl]pyrimidin-4-yl}methyl)amino]cyclobutyl}methanol 
• 1132814-32-4 ethyl 3-[1-(hydroxymethyl)cyclobutylamino]-2-(2,3,4,5-tetrafluorobenzoyl)acrylate 

Relevant articles and documents

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

Pyrimidine compound and anti-rotavirus composition

A pyrimidine compound of the formula [I]wherein R1 is H, C1-C4 lower alkyl, halogen atom, -OH, C1-C4 lower alkoxy, C1-C6 hydroxy(lower)alkoxy or -NH2; R2 is H, -NH2 or -NHCOCH3; R3 is -NR5(CH2)i-CH2OH; R4 is H, halogen atom, -NH2, -CN, -CHO, -CH2OH, -COOH