70780-84-6

Basic information

• Product Name: 1-Aminocyclobutane-1-carbonitrile
• Synonyms: 1-Aminocyclobutane-1-carbonitrile;1-AMinocyclobutane-1-carbonitrile(hcl)
• CAS NO: 70780-84-6
• Molecular Formula: C5H8N2
• Molecular Weight: 96.13
• EINECS: 200-589-5
• Mol File: 70780-84-6.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 198.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.06±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.18±0.20(Predicted)
• CAS DataBase Reference: 1-Aminocyclobutane-1-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Aminocyclobutane-1-carbonitrile(70780-84-6)
• EPA Substance Registry System: 1-Aminocyclobutane-1-carbonitrile(70780-84-6)

Safety Data

• Hazardous Substances Data: 70780-84-6(Hazardous Substances Data)

Usage

General Description

1-Aminocyclobutane-1-carbonitrile is a chemical compound with the molecular formula C5H8N2. It is a cyclic organic compound containing a four-membered cyclobutane ring and a carbonitrile group (–C≡N) bonded to an amino group. It is used as a building block in organic synthesis for the preparation of various pharmaceuticals and agrochemicals. The compound has potential applications in medicinal chemistry, particularly in the development of drugs targeting the central nervous system and other therapeutic areas. Additionally, it is used as a precursor in the synthesis of heterocyclic compounds and may have other industrial applications in research and development.

Upstream product

• 1191-95-3 cyclobutanone 
• 773837-37-9 sodium cyanide 
• 1251923-90-6 N-Boc-1-aminocyclobutanecarbonitrile 

Downstream Products

• 215597-35-6 methyl 1-aminocyclobutanecarboxylate 
• 180205-34-9 (1-aminocyclobutyl)methanol 

Relevant articles and documents

Photoreactive fused aziridinylpiperazines on the background of 4-substituted chalcones and their benzimidazolic analogs

The reaction of bromo-substituted chalcones with various diamino-compounds leads to the fused heterocyclic products, aziridinylpiperazines, exhibiting photoreactivity in the crystalline state. Crystals of 4-nitrosubstituted compounds of this family change their color from yellowish to deep violet-blue, 4-cyanosubstituted ones – from yellowish to pink at UV irradiation. Discussion on the mechanism of this phototransformation is still in progress, however, several facts points to the free radial nature of the photogenerated colored semi-products stabilized only by crystalline state of the irradiated samples. Formation of a mixture of positional isomers at interaction of bromo-chalcones with asymmetric diamines of aliphatic/alicyclic or aromatic series at synthesis of the title compounds is of significant interest as well.

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

PHENYLIMIDAZOLIDINES

A compound selected from the group consisting of compounds of the formula STR1 wherein R 1 and R 2 are individually selected from the group consisting of--CN,--NO 2, halogen,--CF 3, free carboxy, salified carboxy, and carboxy esterified with lower alkyl;-