70780-84-6

Basic information

• Product Name: 1-Aminocyclobutane-1-carbonitrile
• Synonyms: 1-Aminocyclobutane-1-carbonitrile;1-AMinocyclobutane-1-carbonitrile(hcl)
• CAS NO: 70780-84-6
• Molecular Formula: C5H8N2
• Molecular Weight: 96.13
• EINECS: 200-589-5
• Mol File: 70780-84-6.mol

Chemical Properties

• Boiling Point: 198.2±23.0 °C(Predicted)
• Appearance: /
• Density: 1.06±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 5.18±0.20(Predicted)
• CAS DataBase Reference: 1-Aminocyclobutane-1-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Aminocyclobutane-1-carbonitrile(70780-84-6)
• EPA Substance Registry System: 1-Aminocyclobutane-1-carbonitrile(70780-84-6)

Safety Data

• Hazardous Substances Data: 70780-84-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
1-Aminocyclobutane-1-carbonitrile is used as a key intermediate in the synthesis of various pharmaceuticals for its ability to contribute to the development of drugs targeting the central nervous system and other therapeutic areas. Its unique structure allows for the creation of molecules with specific biological activities, making it a valuable component in medicinal chemistry.
Used in Agrochemical Industry:
As a building block in organic synthesis, 1-Aminocyclobutane-1-carbonitrile is also used in the agrochemical industry for the preparation of various agrochemicals. Its incorporation into these compounds can enhance their effectiveness in agricultural applications, such as pest control and crop protection.
Used in Heterocyclic Compound Synthesis:
1-Aminocyclobutane-1-carbonitrile is utilized as a precursor in the synthesis of heterocyclic compounds, which are important in various fields, including pharmaceuticals, materials science, and organic chemistry. Its role in the formation of these compounds highlights its versatility and importance in chemical research and development.
Used in Research and Development:
1-Aminocyclobutane-1-carbonitrile's potential applications extend beyond direct synthesis, as it is also used in research and development for exploring new chemical reactions, understanding molecular interactions, and developing innovative applications across various industries. Its presence in the lab setting underscores its role in advancing scientific knowledge and technological advancements.

Upstream product

• 1251923-90-6 N-Boc-1-aminocyclobutanecarbonitrile 
• 1191-95-3 cyclobutanone 
• 773837-37-9 sodium cyanide 

Downstream Products

• 215597-35-6 methyl 1-aminocyclobutanecarboxylate 
• 180205-34-9 (1-aminocyclobutyl)methanol 

Relevant articles and documents

Photoreactive fused aziridinylpiperazines on the background of 4-substituted chalcones and their benzimidazolic analogs

The reaction of bromo-substituted chalcones with various diamino-compounds leads to the fused heterocyclic products, aziridinylpiperazines, exhibiting photoreactivity in the crystalline state. Crystals of 4-nitrosubstituted compounds of this family change their color from yellowish to deep violet-blue, 4-cyanosubstituted ones – from yellowish to pink at UV irradiation. Discussion on the mechanism of this phototransformation is still in progress, however, several facts points to the free radial nature of the photogenerated colored semi-products stabilized only by crystalline state of the irradiated samples. Formation of a mixture of positional isomers at interaction of bromo-chalcones with asymmetric diamines of aliphatic/alicyclic or aromatic series at synthesis of the title compounds is of significant interest as well.

Synthesis of: N -unsubstituted cycloalkylimines containing a 4 to 8-membered ring

Primary cycloalkylimines with a 4 to 8-membered ring were synthesized by dehydrocyanation of the corresponding α-aminonitriles on solid potassium hydroxide via a vacuum gas-solid reaction. Imine-enamine tautomerism has been demonstrated at room temperature for the most kinetically stable derivatives.

Design and Synthesis of Fsp3-Rich, Bis-Spirocyclic-Based Compound Libraries for Biological Screening

The exploration of innovative chemical space is a critical step in the early phases of drug discovery. Bis-spirocyclic frameworks occur in natural products and other biologically relevant metabolites and show attractive features, such as molecular compactness, structural complexity, and three-dimensional character. A concise approach to the synthesis of bis-spirocyclic-based compound libraries starting from readily available commercial reagents and robust chemical transformations has been developed. A number of novel bis-spirocyclic scaffold examples, as implemented in the European Lead Factory project, is presented.

Design and synthesis of dipeptidyl nitriles as potent, selective, and reversible inhibitors of cathepsin C

A series of dipeptide nitriles with a thienyl alanine in P2 were identified as potent and selective cathepsin C inhibitors. Incorporation of a substituted cyclopropyl moiety in P1 effectively protects these derivatives against hydrolase activity in whole blood.

PHENYLIMIDAZOLIDINES

A compound selected from the group consisting of compounds of the formula STR1 wherein R 1 and R 2 are individually selected from the group consisting of--CN,--NO 2, halogen,--CF 3, free carboxy, salified carboxy, and carboxy esterified with lower alkyl;-