180207-28-7Relevant academic research and scientific papers
SUBSTITUTED HETEROCYCLICS WITH THERAPEUTIC ACTIVITY IN HIV
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Paragraph 0251; 0255-0257, (2021/05/29)
Substituted heterocyclic substituted pyrrole carboxamide compounds such as those represented by Formula I or Formula II are provided herein. Such compounds, or pharmaceutically acceptable salts thereof, can be used in the treatment of HIV infection and re
Preclinical Optimization of gp120 Entry Antagonists as anti-HIV-1 Agents with Improved Cytotoxicity and ADME Properties through Rational Design, Synthesis, and Antiviral Evaluation
Curreli, Francesca,Ahmed, Shahad,Benedict Victor, Sofia M.,Iusupov, Ildar R.,Belov, Dmitry S.,Markov, Pavel O.,Kurkin, Alexander V.,Altieri, Andrea,Debnath, Asim K.
, p. 1724 - 1749 (2020/03/10)
We previously reported a milestone in the optimization of NBD-11021, an HIV-1 gp120 antagonist, by developing a new and novel analogue, NBD-14189 (Ref1), which showed antiviral activity against HIV-1HXB2, with a half maximal inhibitory concentr
PYRUVATE KINASE ACTIVATORS FOR USE IN TREATING BLOOD DISORDERS
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Page/Page column 185; 186, (2019/03/05)
Described herein are compounds that activate pyruvate kinase R, pharmaceutical compositions and methods of use thereof. These compounds are represented by Formula (I): Formula (I) wherein R', R2, L', and L2 are as defined herein.
