590-90-9Relevant academic research and scientific papers
Chemoselective Oxidation of Secondary Hydroxy Groups by the Molybdenum Hexacarbonyl/Cetylpyridinium Chloride/t-Butyl Hydroperoxide System
Yamawaki, Kazumasa,Yoshida, Tsutomu,Suda, Takashi,Ishii, Yasutaka,Ogawa, Masaya
, p. 59 - 60 (1986)
The system molybdenum hexacarbonyl/cetylpyridinium chloride/t-butyl hydroperoxide in benzene is used for the chemoselective oxidation of secondary hydroxy compounds to the corresponding carbonyl derivatives.
Enzymatic syntheses of 13C-enriched geranylgeranyl diphosphate and casbene from 13C-labeled isopentenyl diphosphate
Huang, Qiulong,Huang, Kexue,Scott
, p. 2033 - 2036 (1998)
Geranylgeranyl diphosphate and casbene were synthesized in high yields from [4-13c]-3-methyl-3- butenyl diphosphate, using coupled enzyme reactions.
HIGHLY SELECTIVE OXIDATION OF SECONDARY HYDROXYL FUNCTIONS USING THE VO(acac)2-t-BuOOH SYSTEM
Kaneda, Kiyotomi,Kawanishi, Yasuyuki,Jitsukawa, Koichiro,Teranishi, Shiichiro
, p. 5009 - 5010 (1983)
The VO(acac)2-t-BuOOH system shows high oxidation reactivity for secondary alkohols to give ketones.
Process for preparing 4-hydroxy-2-butanone
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Paragraph 0024-0044, (2020/12/31)
The invention provides a process for preparing 4-hydroxy-2-butanone. Amino acid is used as a catalyst to catalyze the condensation reaction of formaldehyde and acetone at normal temperature, so as tosynthesize 4-hydroxy-2-butanone in one step. The yield of the prepared 4-hydroxy-2-butanone is high, the purity reaches 98%, the production cost is reduced, the corrosion effect caused by the use of astrong base catalyst is avoided, the catalyst and the solvent can be recycled for 10 times or more, and the whole synthesis process is economical and environment-friendly.
Hydroxycarbonyl compound (by machine translation)
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Paragraph 0070, (2020/01/31)
After the separated and purified efficiently and easily by hydroxycarbonyl compound [a] of production method. [Solution] a carbonyl compound having a hydrogen atom at α-position with paraformaldehyde, acidic or basic catalyst is added to the environment is not reacting with the method. Figure 1 [drawing] (by machine translation)
Preparation method of hydroxyl ketone compound
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Paragraph 0024-0036; 0039-0048; 0055-0059, (2020/07/12)
The invention discloses a preparation method of a hydroxyl ketone compound. The method comprises a step of converting dihydric alcohol into a hydroxyl ketone compound in the presence of a copper-basedcatalyst, namely a conversion step, and the reaction conditions of the conversion step are as follows: the reaction temperature is 200-400 DEG C, the reaction pressure is 0.01-0.5 MPa, and the liquidhour space velocity is 0.1-10 h. The method has a high raw material conversion rate and high selectivity of the hydroxyl ketone compound with terminal hydroxyl, and is easy to implement industrially.
Reductive Electrochemical Activation of Molecular Oxygen Catalyzed by an Iron-Tungstate Oxide Capsule: Reactivity Studies Consistent with Compound i Type Oxidants
Bugnola, Marco,Shen, Kaiji,Haviv, Eynat,Neumann, Ronny
, p. 4227 - 4237 (2020/05/05)
The reductive activation of molecular oxygen catalyzed by iron-based enzymes toward its use as an oxygen donor is paradigmatic for oxygen transfer reactions in nature. Mechanistic studies on these enzymes and related biomimetic coordination compounds designed to form reactive intermediates, almost invariably using various "shunt" pathways, have shown that high-valent Fe(V)=O and the formally isoelectronic Fe(IV) =O porphyrin cation radical intermediates are often thought to be the active species in alkane and arene hydroxylation and alkene epoxidation reactions. Although this four decade long research effort has yielded a massive amount of spectroscopic data, reactivity studies, and a detailed, but still incomplete, mechanistic understanding, the actual reductive activation of molecular oxygen coupled with efficient catalytic transformations has rarely been experimentally studied. Recently, we found that a completely inorganic iron-tungsten oxide capsule with a keplerate structure, noted as {Fe30W72}, is an effective electrocatalyst for the cathodic activation of molecular oxygen in water leading to the oxidation of light alkanes and alkenes. The present report deals with extensive reactivity studies of these {Fe30W72} electrocatalytic reactions showing (1) arene hydroxylation including kinetic isotope effects and migration of the ipso substituent to the adjacent carbon atom ("NIH shift"); (2) a high kinetic isotope effect for alkyl C - H bond activation; (3) dealkylation of alkylamines and alkylsulfides; (4) desaturation reactions; (5) retention of stereochemistry in cis-alkene epoxidation; and (6) unusual regioselectivity in the oxidation of cyclic and acyclic ketones, alcohols, and carboxylic acids where reactivity is not correlated to the bond disassociation energy; the regioselectivity obtained is attributable to polar effects and/or entropic contributions. Collectively these results also support the conclusion that the active intermediate species formed in the catalytic cycle is consistent with a compound I type oxidant. The activity of {Fe30W72} in cathodic aerobic oxidation reactions shows it to be an inorganic functional analogue of iron-based monooxygenases.
High purity 1,3-butanediol and its preparation method
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Paragraph 0172; 0181; 0182, (2019/05/25)
The present invention relates to a high purity 1,3-butanediol and a preparation method thereof. The preparation method of the present invention comprises: a step (a) of mixing distilled water, a buffer solution and paraformaldehyde to obtain a mixture, and heating the mixture to prepare formaldehyde; a step (b) of mixing formaldehyde of the step (a) (s100) with acetone, and making the formaldehyde of the step (a) react with the acetone to prepare a mixed solution as an intermediate; a step (c) of reducing the intermediate of the step (b) (s200) to prepare 1,3-butanediol; and a step (d) of deodorizing/purifying 1,3-butanediol of the step (c) (s300). According to the present invention, the high purity 1,3-butanediol prepared by the preparation method not only can be used as raw material for various resins such as polyester resins, alkyd resins, urethane resins, urethane coatings and the like as industrial uses, but also can be diversely used in other fabric softeners, pharmaceuticals, dyestuffs and others. Further, the high purity 1,3-butanediol not only can be used as a moisturizer for a cosmetic composition, perfume and hair since slight intoxication is not generated although the high purity 1,3-butanediol is stored for a long period, but also can be used in a preparation for spice of food products or the like.(AA) Start(BB) End(S10) Step of preparing high purity formaldehyde(S200) Step of preparing an intermediate(S300) Step of reducing the intermediate(S400) Step of performing deodorizing and purifying operationsCOPYRIGHT KIPO 2019
Production method of 4-hydroxy-2-butanone
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Paragraph 0018-0027, (2019/10/01)
Belonging to the field of fine chemicals, the invention discloses a production method of 4-hydroxy-2-butanone, and solves the problem of low yield of existing synthetic methods. The method provided bythe invention includes the steps of: adding 1, 3-butanediol, a catalyst, an assistant, water and a water-carrying agent into a reaction kettle, and performing heating to 55-60DEGC; adding hydrogen peroxide dropwise into the mixed solution, and conducting reduced pressure distillation of water; stopping adding hydrogen peroxide, and further performing stirring for 1-1.5h to distill the water-carrying agent out; controlling the temperature of the system not higher than 60DEGC, and conducting reduced pressure rectification to obtain the final product 4-hydroxy-2-butanone. By adding the assistant, 1, 3-butanediol can better participate in the reaction, and the conversion rate can be improved. The chemical reaction carried out in the invention is carried out under a negative pressure condition, and the temperature is controlled not higher than 60DEG C, thus avoiding the generation of methyl vinyl ketone; and in a negative pressure system, the reaction can be fully carried out under a low temperature condition, the product is easier to distill, and impurities are not easily produced.
Aerobic Oxidation of Secondary Alcohols with Nitric Acid and Iron(III) Chloride as Catalysts in Fluorinated Alcohol
Mo?ina, ?tefan,Iskra, Jernej
, p. 14579 - 14586 (2019/11/14)
Fluorinated alcohols as solvents strongly influence and direct chemical reaction through donation of strong hydrogen bonds while being weak acceptors. We used 1,1,1,3,3,3-hexafluoro-2-propanol (HFIP) as the activating solvent for a nitric acid and FeCl3-catalyzed aerobic oxidation of secondary alcohols to ketones. Reaction proceeded selectively with excellent yields with no reaction on the primary alcohol group. Oxidation of benzyl alcohols proceeds selectively to aldehydes with only HNO3 as the catalyst, while reaction on tertiary alcohols proceeds through dehydration and dimerization. A mechanistic study showed in situ formation of NOCl that converts alcohol into alkyl nitrite, which in the presence of Fe3+ ions and fluorinated alcohol decomposes into ketone. The study indicates that iron(III) acts also as the single-electron transfer catalyst in regeneration of NOCl reactive species.
