18023-30-8

Basic information

• Product Name: 2,2-diMethyl-2,3-dihydro-1H-indole
• Synonyms: 2,2-diMethyl-2,3-dihydro-1H-indole
• CAS NO: 18023-30-8
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.21692
• Mol File: 18023-30-8.mol
• Article Data: 3

Chemical Properties

• Melting Point: 138 °C
• Boiling Point: 90-92 °C(Press: 13 Torr)
• Appearance: /
• Density: 0.962±0.06 g/cm3(Predicted)
• PKA: 5.33±0.40(Predicted)
• CAS DataBase Reference: 2,2-diMethyl-2,3-dihydro-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2-diMethyl-2,3-dihydro-1H-indole(18023-30-8)
• EPA Substance Registry System: 2,2-diMethyl-2,3-dihydro-1H-indole(18023-30-8)

Safety Data

• Hazardous Substances Data: 18023-30-8(Hazardous Substances Data)

Usage

General Description

2,2-dimethyl-2,3-dihydro-1H-indole is a chemical compound with the molecular formula C11H13N. It is a bicyclic nitrogen-containing compound that is commonly used in the pharmaceutical industry as a building block for the synthesis of various drugs. It is also known for its role as an intermediate in the production of dyes and other organic compounds. This chemical is also used as a precursor for the synthesis of indole-based natural products and is a versatile starting material for the preparation of various heterocyclic compounds. The compound has also been studied for its potential pharmacological properties, including its activity as a serotonin receptor agonist.

Upstream product

• 106898-71-9 2-isopropylaminobenzyl alcohol 
• 153278-96-7 1-acetyl-2,2-dimethyl-2,3-dihydroindol-3-one 
• 3929-78-0 2,2-dimethyl-1,2-dihydro-3H-indol-3-one 

Relevant articles and documents

SUBSTITUTED, SATURATED AND UNSATURATED N-HETEROCYCLIC CARBOXAMIDES AND RELATED COMPOUNDS FOR THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted, saturated and unsaturated N-heterocyclic carboxamides and related compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., cancer, lysosomal storage disorder, neurodegenerative disorder, inflammatory disorder, in a patient.

Indoline and piperazine containing derivatives as a novel class of mixed D2/D4 receptor antagonists. Part 1: Identification and structure-activity relationships

Optimization of the lead compound 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2,3-dihydro-indol-1-yl)-ethanone 1 by systematic structure-activity relation (SAR) studies lead to two potent compounds 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 2n and 2-[-4-(4-chloro-benzyl)-piperazin-1-yl]-1-(2-methy-2,3-dihydro-indol-1-yl)- ethanone 7b. Their related synthesis was also reported.