18024-34-5Relevant academic research and scientific papers
Electrophilic additions of mono-, di- and tri-gold units to the isoelectronic 2- and 2- anions
Rossell, Oriol,Seco, Miquel,Segales, Gloria
, p. 225 - 234 (1995)
The reaction of 2 with or in tetrahydrofuran gives the mixed manganese-gold clusters 3-H)(μ-AuPR3)> (R = Ph (1) or Me (2)) and 23-H)Au>2(μ-diphos)> (diphos = dppe (3) or dppm (4)).The reaction between the same manganese anion and produces 3-H)Au>3(triphos)>3- (5), 3-H)Au>2(triphos)(AuCl)>2- (6) or 3-H)Au>(triphos)(AuCl)2>- (7), depending on the molar ratio of the reagents.Isoelectronic iron-goldcomplexes (3-x)(triphos)(AuCl)x>(3-x)- (x = 0 (8), 1 (9) or 2 (10) were obtained by the reaction of the trinuclear 2- anion with in the appropriate molar ratio.Attempts to obtain mixed manganese-iron-gold clusters resulted in a mixture of compounds, the nature of which has been explained in terms of metal-ligand redistribution processes.Keywords: Gold; Manganese; Iron; Metal-metal bonds; Clusters; Electrophilic addition
Luminescent gold(i) macrocycles with diphosphine and 4,4'-bipyridyl ligands
Brandys, Marie-Claude,Jennings, Michael C.,Puddephatt, Richard J.
, p. 4601 - 4606 (2000)
The complexes [{-Ph2P(CH2)aPPh2AuNC5H4C5H4NAu-y2l:+ [CF3CVL (/; = 1-6) were prepared as colourless, air-stable solids by reaction of silver trifluoroacetate with the corresponding precursor complex [(CH2)(Ph2PAuCl)2], and
An efficient approach to chloro(organophosphine) gold(i) complexes for the synthesis of auranofin
Wang, Junchang,Mi, Xuemeng,Wang, Jiazhe,Yang, You
supporting information, p. 634 - 637 (2017/08/15)
A practical and efficient synthesis of chloro(organophosphine) gold(i) complexes is reported. Employment of 4,4′-dihydroxydiphenyl sulfide as a safe and non-irritating reductant is highlighted for the generation of Au(i)-S intermediates, which could be trapped by mono- and bidentate phosphine ligands to provide organophosphine gold(i) complexes. The utility of the present method is further demonstrated by the synthesis of the antiarthritic drug auranofin.
Method for preparing organic phosphonic gold chloride (I) compound
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Paragraph 0055; 0056; 0057; 0058; 0059; 0060, (2016/12/16)
The invention discloses a method for preparing an organic phosphonic gold chloride (I) compound. The method comprises the following steps: (1) adding chloroauric acid hydrated salt into a reaction container, dissolving with water, and uniformly stirring in an ice-water bath; (2) keeping the temperature of the ice water in the reaction container, dripping a glucosinolates diaryl compound or a derivative of the glucosinolates diaryl compound, and stirring uniformly; (3) dripping a mixed liquid of phosphine-containing ligand and ethanol into the reaction container one droplet by one droplet, removing the ice-water bath, recovering the room temperature naturally, and stirring for 2-5 hours; (4) stopping stirring, performing suction filtration, washing with cold methanol, dissolving the collected solid with an organic solvent, and performing suction filtration again so as to remove insoluble matters; (5) performing concentration spinning drying on the solution, recrystallizing with a solvent, and performing suction filtration again, thereby obtaining the organic phosphonic gold chloride (I) compound. As the glucosinolates diaryl compound or the derivative of the glucosinolates diaryl compound is taken as a reduction reagent, and due to reaction between the chloroauric acid hydrated salt and the phosphine-containing ligand in an ethanol-water system, environment-friendly, safe and efficient production of the organic phosphonic gold chloride (I) compound can be achieved, and moreover, industrial application of the organic phosphonic gold chloride (I) compound is facilitated.
Synthesis and structural studies of some gold(I) complexes containing selenoureato ligands
Molter, Anja,Mohr, Fabian,Rust, Joerg,Lehmann, Christian W.
, p. 10586 - 10591,6 (2012/12/12)
N,N-Diethyl-N′-4-nitrobenzoylselenourea (HLSe) reacts with the mono- and dinuclear phosphine gold(I) chloro complexes [AuCl(PR 3)] (R=Ph, o-tol, Et) and [Au2Cl2(μ-P-P)] (P-P=dppm, dppe, dppp, dppb, dppf) in the presence of base to give gold(I) phosphine selenoureato complexes [Au(LSe)(PR3)] [R=Ph (1), o-tol (2), Et (3)], [Au2(LSe)2(μ-P-P)] [P-P=dppm (4), dppe (5), dppp (6), dppb (7), dppf (8)] in excellent yields. The compounds were fully characterised by spectroscopic methods and, in the case of compounds 1, 5 and 8, by single crystal X-ray diffraction. The compounds consist of a gold atom bound in linear fashion to the phosphine ligand and the selenium atom from the deprotonated acylselenourea. These complexes thus represent the first examples of acylselenoureato metal compounds in which the ligands do not adopt the typical O,Se chelating mode but rather coordinate to the metal only through the selenium atom.
Synthesis, structures and anti-malaria activity of some gold(i) phosphine complexes containing seleno- and thiosemicarbazonato ligands
Molter, Anja,Rust, Joerg,Lehmann, Christian W.,Deepa, Ganesh,Chiba, Peter,Mohr, Fabian
, p. 9810 - 9820 (2011/12/03)
A series of both mono- and dinuclear gold(i) phosphine complexes containing monoanionic seleno- and thiosemicarbazones as ligands were prepared and fully characterized by spectroscopic methods and, in some cases, by single crystal X-ray diffraction. The in vitro anti-malaria activity of some of these compounds was investigated in chloroquine sensitive strains of Plasmodium falciparum. The IC50 results show that the sulfur containing compounds exhibit activity similar to that of chloroquine, whilst the selenium derivatives display only moderate anti-malaria activity.
Polymeric and macrocyclic gold(I) complexes with bridging dithiolate and diphosphine ligands
Hunks, William J.,Jennings, Michael C.,Puddephatt, Richard J.
, p. 3605 - 3616 (2008/10/09)
The reaction of digold(I) diphosphine complexes [Au2(O2CCF3)2(μ-Ph2P-X -PPh2)] with dithiols HS-Y-SH can give either macrocyclic complexes [Au2(μ-S-Y-S)(μ-Ph2P-X-PPh2)] or polymeric complexes [Au2(μ-S-Y-S)(μ-Ph2P-X-PPh2)] n. The structures of the macrocyclic complex [Au2{μ-(S-4-C6H4)2S}{μ -Ph2P(CH2)4PPh2}], and the polymeric complexes [Aun{μ-(S-CH2CO2CH2CH 2O)2-1,4-C6H4}n(μ- trans-Ph2PCH{double bond, long}CHPPh2)n] and [Aun{μ-(S-CH2CO2CH2CH 2O)2-1,5-C10H6}n(μ -trans-Ph2PCH{double bond, long}CHPPh2)n] have been determined. Evidence is presented that the complexes exist primarily as macrocycles in solution and that, in favorable cases, ring-opening polymerization occurs during crystallization.
Binary and ternary cluster complexes containing gold-selenium, gold-indium-selenium and gold-gallium-tellurium
Olkowska-Oetzel, Jolanta,Sevillano, Paloma,Eichhoefer, Andreas,Fenske, Dieter
, p. 1100 - 1106 (2007/10/03)
Reactions of gold phosphane complexes [(AuX)(PR3)] (X = Cl, Br, I; R = organic moiety) with Se(SiMe3)2 lead to the formation of gold complexes with chalcogenide bridges. The reaction of the complex [Ph3PAuCl] and tBuSe(SiMe3) gives the cluster [Au5Se2(PPh3)4]Cl (1). The in situ preparation of the complex [(AuCl)2dpph] [dpph = Ph 2P(CH2)6PPh2] by reaction of dpph with [Me2SAuCl], and subsequent reaction with Se(SiMe 3)2, leads to the formation of [(Au3Se) 2(dpph)3]Cl2 (2). Reactions of the gold(I) complex [(AuCl)2dpppe] [dpppe = Ph2P(CH2) 5PPh2] with Se(SiMe3)2 and InCl 3 in different molar ratios lead to the formation of [Au 10Se4(dpppe)4]InCl5 (3) and [Au 4(SeInCl3)2(dpppe)2] (4). The reaction of [(AuCl)2dpph] with Te(SiMe3)2 and GaCl3 produces the isostructural cluster compound [Au 4(TeGaCl3)2(dpph)2] (5). From the reaction of Se(SiMe3)2 with [(AuCl)2dppe] [dppe = Ph2P(CH2)2PPh2] and InCl 3 [Au8Se4In(dppe)4](InCl 4)3 6 can be isolated. The structures of 1-6 were determined by X-ray diffraction. Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2004.
N-Metallation of MS2N2 rings. X-ray crystal structures of [(η5-C5Me5)Ir(S 2N2)Au(PPh3)][ClO4], [{η 5-C5Me5Ir(S2N2)Au} 2 (μ2-dppm)][ClO4]2 and [Au(dppeS-P)Cl]2
Aucott, Stephen M.,Bhattacharyya, Pravat,Milton, Heather L.,Slawin, Alexandra M. Z.,Woollins, J. Derek
, p. 1466 - 1469 (2007/10/03)
Bimetallic complexes [(η5-C5R5) M(S2N2)Au(PPh3)][ClO4] and tetrametallic species [{(η5-C5R5) M(S 2N2)Au}2(μ2-P^P)][ClO 4]2 (R = H, M = Co; R = Me, M = Ir; P^P = dppm or dppe) can be prepared by treatment of [(η5-C5R 5)M(S2N2)] with gold(I) electrophiles generated by chloride abstraction from [AuCl(PPh3)] or [(AuCl) 2(μ2-P^P)]. X-Ray crystallography of [(η5-C 5Me5) Ir(S2N2)Au(PPh 3)][ClO4] and [{(η5-C5Me 5)Ir(S2N2)Au}2(η 2-dppm)][ClO4]2 confirms auration of the metal-bound nitrogen atom of the MS2N2 ring. π-Stacking of theMS2N2 rings occurs within both structures.
Synthesis, characterization and electrochemical studies of the heterometallic diclusters [{Fe2(μ-CO)(CO)6(μ-PPh2)Au}2(d iphosphine)] (diphosphine=dppm, dppip, dppe, dppp)
Ferrer, Montserrat,Julia, Anna,Reina, Roser,Rossell, Oriol,Seco, Miquel,De Montauzon, Dominique
, p. 147 - 153 (2007/10/03)
Treatment of [(ClAu)2(diphosphine)] {diphosphine=bis(diphenylphosphino)methane (dppm), bis(diphenylphosphino)isopropane (dppip), 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-bis(diphenylphosphino)propane (dppp)} with two equivalents of the anion [Fe2(μ-CO)(CO)6(μ-PPh2)]- in the presence of TlBF4 gives the new heterometallic diclusters [{Fe2(μ-CO)(CO)6(μ-PPh2)Au}2(d iphosphine)] that have been isolated and characterized. Their 31P-NMR spectra show different patterns as a function of the diphosphine ligand. The electrochemical behavior of these compounds has been investigated and compared with that of the mono- [Fe2(μ-CO)(CO)6(μ-PPh2)(μ-AuPPh3)] and tricluster [{Fe2(μ-CO)(CO)6(μ-PPh2)Au}3(t riphos)] derivatives.
