180253-72-9

Upstream product

• 20098-48-0 3,4,5-trichloronitrobenzen 
• 930-69-8 sodium thiophenolate 
• 98137-94-1 1-bromo-2,6-dichloro-4-nitrobenzene 
• 108-98-5 thiophenol 
• 3107-19-5 3,5-dichloro-4-fluoro-nitrobenzene 

Downstream Products

• 1620782-56-0 N³-(4-benzenesulfonyl-3,5-dichlorophenyl)-1H-[1,2,4]triazole-3,5-diamine 
• 1620782-55-9 N³-(4-benzenesulfinyl-3,5-dichlorophenyl)-1H-[1,2,4]triazole-3,5-diamine 
• 1620878-53-6 (Z)-methyl N'-cyano-N-(3,5-dichloro-4-(phenylthio)phenyl)carbamimidothioate 
• 1620782-81-1 1,3-dichloro-5-isothiocyanato-2-phenylsulfanylbenzene 
• 1620782-54-8 N³-(3,5-dichloro-4-phenylsulfanylphenyl)-1H-[1,2,4]triazole-3,5-diamine 

Relevant academic research and scientific papers

ANTIVIRAL TRIAZOLE DERIVATIVES

The present invention discloses compounds of Formula I: wherein the variables in Formula I are defined as described herein. Also disclosed are pharmaceutical compositions containing such compounds and methods for using the compounds of Formula I in the prevention or treatment of HCV infection.

Triazine derivatives, their production and use

The present invention relates to compounds represented by the formula: wherein ring H represents an optionally substituted aromatic heterocyclic group or an optionally substituted alicyclic hydrocarbon group; X and Y independently represent a single bond, —O—, a group of the formula: —S(O)m— wherein m is 0, 1 or 2, a group of the formula: —NR8— wherein R8represents a hydrogen atom, an alkyl group or an acyl group, —CO— or an optionally substituted methylene group; —A—B— represents —N═CH—, —CH═N—, —N═N— or —CH═CH—; R1represents a hydrogen atom, a halogen atom, an optionally substituted alkyl group which may be bonded through a hetero atom or an acyl group; R2and R3independently represent a hydrogen atom, a halogen atom or an optionally substituted alkyl group; R4represents a hydrogen atom or a halogen atom; R5represents a hydrogen atom, an optionally substituted alkyl group or an acyl group; R6and R7independently represent a hydrogen atom or R6and R7may form a chemical bond together with each other; and D represents —CH2— or —CO—; or a salt thereof. These compounds and salts thereof are useful as anti-protozoal agents.

Reductively activated polar" nucleophilic aromatic substitution. IV [1]. Thermal and photochemical behavior of polychloro and polyfluoro-nitrobenzenes in front of soft nucleophiles

The nucleophilic aromatic substitution of pentachloronitrobenzene (PCNB) with benzenethiolate and benzeneselenide anions in aqueous solution give rise to fast nitro group substitution in both cases. In the same conditions, pentafluoronitrobenzene (PFNB) and 3,4,5-trichloronitrobenzene (TCNB) undergo substitution of the halogen atom placed in para position with respect to the nitro group. Mechanistic studies suggest that the reactions of PCNB and PFNB (substitution of very electronegative leaving groups) follow a mechanism that includes a "polar" attack of the nucleophile on the aromatic substrate in the first step and a fast "radical" evolution of the o-complex intermediate. On the other hand, the chloride substitution in the TCNB reactions follows the classical SNAr mechanism. The photochemical reactions of PCNB, PFNB and TCNB in the presence of nucleophiles (electron donors) lead in all cases to photoreduction products (anilines) probably through the aromatic radical anion. Springer-Verlag 1996.