1802913-21-8 Usage
Uses
Used in Pharmaceutical Industry:
TCO-PEG4-Acid is used as a drug conjugation agent for enhancing the stability and solubility of therapeutic agents. Its ability to react with primary amine groups allows for the attachment of drugs to targeting moieties or other functional groups, improving the overall pharmacokinetics and biodistribution of the drug molecules.
Used in Bioconjugation:
In the field of bioconjugation, TCO-PEG4-Acid serves as a linker for the covalent attachment of biologically active molecules, such as peptides, proteins, or nucleic acids, to various carriers or supports. This enables the creation of novel bioconjugates with tailored properties and functions for applications in diagnostics, therapeutics, and research.
Used in Drug Delivery Systems:
TCO-PEG4-Acid is utilized as a component in the design of drug delivery systems, where it aids in the conjugation of therapeutic agents to nanoparticles, liposomes, or other carriers. This enhances the targeting, release, and overall effectiveness of the drug delivery platform, leading to improved treatment outcomes.
Used in Chemical Biology Research:
In chemical biology research, TCO-PEG4-Acid is employed as a tool for the study of protein-protein interactions, enzyme activity, and other biological processes. Its reactivity with tetrazine in an IEDDA reaction allows for the rapid and efficient formation of stable linkages between molecules, facilitating the investigation of complex biological systems.
Used in Materials Science:
In the field of materials science, TCO-PEG4-Acid can be used for the development of functional materials with tailored properties. Its ability to form stable covalent bonds with a variety of substrates enables the creation of novel materials with applications in sensors, coatings, and other advanced technologies.
Check Digit Verification of cas no
The CAS Registry Mumber 1802913-21-8 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,8,0,2,9,1 and 3 respectively; the second part has 2 digits, 2 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 1802913-21:
(9*1)+(8*8)+(7*0)+(6*2)+(5*9)+(4*1)+(3*3)+(2*2)+(1*1)=148
148 % 10 = 8
So 1802913-21-8 is a valid CAS Registry Number.
1802913-21-8Relevant academic research and scientific papers
Rahim, Maha K.,Kota, Rajesh,Haun, Jered B.
, p. 352 - 360 (2015)
The bioorthogonal cycloaddition reaction between tetrazine and trans-cyclooctene (TCO) is rapidly growing in use for molecular imaging and cell-based diagnostics. We have surprisingly uncovered that the majority of TCOs conjugated to monoclonal antibodies using standard amine-coupling procedures are nonreactive. We show that antibody-bound TCOs are not inactivated by trans-cis isomerization and that the bulky cycloaddition reaction is not sterically hindered. Instead, TCOs are likely masked by hydrophobic interactions with the antibody. We show that introducing TCO via hydrophilic poly(ethylene glycol) (PEG) linkers can fully preserve reactivity, resulting in >5-fold enhancement in functional density without affecting antibody binding. This is accomplished using a novel dual bioorthogonal approach in which heterobifunctional dibenzylcyclooctyne (DBCO)-PEG-TCO molecules are reacted with azido-antibodies. Improved imaging capabilities are demonstrated for different cancer biomarkers using tetrazine-modified fluorophore and quantum dot probes. We believe that the PEG linkers prevent TCOs from burying within the antibody during conjugation, which could be relevant to other bioorthogonal tags and biomolecules. We expect the improved TCO reactivity obtained using the reported methods will significantly advance bioorthogonal pretargeting applications.
