180292-07-3Relevant academic research and scientific papers
Asymmetric ring opening reactions of symmetrical N-acylaziridines with thiols catalyzed by chiral dialkyl tartrate-diethylzinc complexes
Hayashi, Masahiko,Ono, Kazuyuki,Hoshimi, Haruhisa,Oguni, Nobuki
, p. 7817 - 7832 (2007/10/03)
The asymmetric ring opening reaction of 1,2-(N-acylimino)cyclohexanes (N- acylaziridines) with some thiols proceeded in the presence of chiral zinc complexes prepared from diethylzinc and dialkyl L-(+)-tartrate to afford trans 2-(N-acylamino)-1-arylthiocyclohexane in up to 93% cc. The enantioselectivity is highly influenced by the molar ratio of the reactants and the nature of chiral dialkyl tartrate. The chemical structure of dialkyl L-(+)-tartrate-zinc complex is discussed on their 1H NMR spectra and molecular weight.
