180298-92-4

Upstream product

• 4651-78-9 2-bromo-1-phenylethylidenemalononitrile 
• 4885-93-2 2-(2,4-dithia-1,5-disodapentan-3-ylidene)propanedinitrile 
• 74-88-4 methyl iodide 
• 19606-83-8 sodium (2,2-dicyano-1-methylthioethen-1-yl)thiolate 
• 20602-68-0 potassium (2,2-dicyano-1-methylsulfanylethen-1-yl)thiolate 

Downstream Products

• 1044860-73-2 5-amino-2-(4-morpholinyl)-7-phenyl-thieno[3,2-b]pyridin-3,6-dicarbonitrile 

Relevant academic research and scientific papers

2-Bromo-1-arylethylidenemalononitriles - Convenient reagents for the regioselective synthesis of fused pyridines

2-Bromo-1-arylethylidenemalononitriles react with conjugated thiolaronitriles to give products of regioselective S alkylation that can be subsequently involved in the Thorpe reaction. Resulting enaminoacrylonitriles form pyridine ring under base catalysis yielding thienodipyridines. According to this common scheme, functionally substituted thieno[3,2-b]pyridines, thiazolo[4,5-b]pyridines, thieno[3,2-b-4,5-h']dipyridines, their hydrogenated analogues, and pyrido[2',3':4,5]thieno[2.3-d]pyrimidine were synthesized.

Heterocondensed thiophenes and thiazoles by Thorpe-Ziegler cyclization

(Chemical Equation Presented) The syntheses of novel thieno-pyridones, thiazolo-pyridones, thiazolo-pyridines and amino- and diamino-dieno-pyridines were described. Simultaneously, it was demonstrated that in these compounds and in the related 3-aminothio

2-Bromo-1-phenylethylidenemalononitrile in the synthesis of thieno[3,2-b]pyridines and thiazolo[4,5-b]pyridines

A novel regioselective synthesis of thieno[3,2-b]pyridines and thiazolo[4,5-b]pyridines from 2-bromo-1-phenylethylidenemalononitrile is proposed. In the case of the thiazolo[4,5-b]pyridines, the intermediate 5-(2,2-dicyano-1-phenylvinyl)thiazoles were separated. Formation of the thiazolo[4,5-b]pyridines was confirmed by x-ray analysis. 1996 Plenum Publishing Corporation.