4885-93-2Relevant academic research and scientific papers
Synthesis of the first novel pyrazole thioglycosides as deaza ribavirin analogues
Abu-Zaied, Mamdouh A.,Elgemeie, Galal H.
, p. 713 - 725 (2017)
This study reports a novel and efficient method for the synthesis of the first reported novel class of thiopyrazoles and their corresponding thioglycosides. These series of compounds were designed through the reaction of hydrazine derivatives with sodium dithiolate salt 2 in EtOH at ambient temperature to give the corresponding sodium 5-amino-4-cyano-1H-pyrazole-3-thiolates 4a-d. The latter compounds were treated with α-acetobromoglucose 6a and α-acetobromogalactose 6b in DMF at ambient temperature to give in an excellent yields the corresponding pyrazole S-glycosides 7a-h. Ammonolysis of the pyrazole thioglycosides 7a-h afforded the corresponding free thioglycosides 8a-h.
A convenient one-pot synthesis of novel functionalized thiophene, thieno[2,3-b] thiophene, thiopyran, and thiopyrano[2,3-b]thiopyran bearing phosphonate groups
Ali, Tarik E.,Assiri, Mohammed A.
, p. 490 - 498 (2021)
Design of some novel functionalized thiophene, thieno[2,3-b]thiophene, thiopyran and thiopyrano[2,3-b]thiopyran bearing phosphonate groups was described in one-pot through simple two steps. The methodology depended on the reaction of three-component of chloroacetyl chloride with triethyl phosphite in the presence of sodium 2,2-dicyanoethene-1,1-bis(thiolate) or sodium (2,2-dicyano-1-methylthioethen-1-yl)thiolate in a certain sequence.
Synthesis of some 2-ylidene-1,3-dithiolanes
Lipin,Ershov,Belikov, M. Yu.,Fedoseev
, p. 147 - 149 (2017)
Convenient procedures have been developed for the synthesis of 2-(1,3-dithiolan-2-ylidene)- malononitriles and 2-cyano-2-(1,3-dithiolan-2-ylidene)acetamides from disodium alk-1-ene-1,1-dithiolates and 1,2-dichloroalkanes, as well as from malononitrile or cyanoacetamide in a one-pot mode.
Annulation of a 1,3-dithiole ring to a sterically hindered o-quinone core. Novel ditopic redox-active ligands
Norkov, Sergey V.,Cherkasov, Anton V.,Shavyrin, Andrey S.,Arsenyev, Maxim V.,Kuropatov, Viacheslav A.,Cherkasov, Vladimir K.
supporting information, p. 273 - 282 (2021/02/27)
The fused 1,3-dithiole spacer seems to be very suitable for the functionalization of sterically hindered o-quinones with additional groups capable of coordination of metal ions and/or possessing a redox activity. An effective method for the synthesis of s
Synthesis and antimicrobial evaluation of novel N-substituted 4-ethylsulfanyl-2-pyridones and triazolopyridines
Azzam, Rasha A.,Elgemeie, Galal H.
, p. 62 - 70 (2018/12/04)
The design and development of new methods for the synthesis of antimicrobial drugs is an important goal currently for medicinal chemistry. Sixteen novel N-substituted-amino-, N-arylsulfonylamino-, and N-aryl-4-ethylsulfanyl-2-pyridones were synthesized. A
Tailored-design Synthesis of Sulfapyrimidine Derivatives
Azzam, Rasha A.
, p. 619 - 627 (2019/01/04)
In this paper, we report an efficient and convenient approach for the synthesis of tailored-design target sulfapyrimidine derivatives expected to show remarkable antimicrobial activities. The approach is based on reacting arylsulfonyl guanidine with α,β-unsaturated carbonyl compounds to afford N-(4,6-diarylpyrimidin-2-yl)arylsulfonamide or with ylidene derivatives to afford N-(6-aryl-5-cyanopyrimidin-2-yl)arylsulfonamide, N-(4-amino-5-cyano-6-(methylthio)-pyrimidin-2-yl)-arylsulfonamide, and N-(5-cyanopyrimidin-2-yl)arylsulfonamide compounds through Michael addition reaction. The structure of the newly synthesized compounds was confirmed from spectral data and elemental analysis.
Sulfur-rich binaphthyl diimide derivative, and preparation method and application thereof
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Paragraph 0054; 0058; 0063, (2019/08/30)
The invention discloses a sulfur-rich binaphthyl diimide derivative, and a preparation method and application thereof, and belongs to the technical field of organic semiconductors. The sulfur-rich binaphthyl diimide derivative, namely the sulfur-containing naphthalene diimide derivative has a structure represented as the following formula (I), wherein R and R are cyano-containing groups, andR, R, R and R are separately selected from alkyl groups with 1-20 carbon atoms. According to the sulfur-containing naphthalene diimide derivative disclosed by the invention, heteroatom functional groups (S) are introduced in 2, 3, 6 and 7 sites of naphthalene rings, and cyano groups are introduced, so that spectrum absorption, the highest occupied molecular orbital (HOMO) value and the lowest unoccupied molecular orbital (LUMO) value of naphthalene diimide derivative molecules can be adjusted by the heteroatom functional groups, and then requirements of various functional materials can be met.
Preparation method and application of organic conjugated micro-molecules rich in nitrogen and sulfur
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Paragraph 0048-0050, (2018/02/04)
The invention discloses organic conjugated micro-molecules rich in nitrogen and sulfur, and a preparation method and application thereof. The organic conjugated micro-molecules rich in nitrogen and sulfur have a structure shown by formula (I), wherein R is hydrogen, alkyl or aryl. The invention also provides a preparation method of the compound of formula (I). The synthetic route of the organic conjugated micro-molecules is simple and effective; raw materials are commercial cheap products, and the synthesis cost is low; and a synthetic method has universality, and can be popularized and applied to synthesis of other various substituent substituted tetrathiophene derivatives. OFETs (organic field-effect transistors) prepared by taking 5,11-dihydro-2,2'-([1,3]) dithiol [4,5-e] pyrazine [2,3-g][1,3] dithiol [4,5-b] quinoxaline-2,8-diidene) di-malononitrile compound (DTYM), synthesized by the method disclosed by the invention, as an organic semiconductor layer are relatively high in mobility and on/off ratio, the highest electron mobility is 0.005cmVs, the on/off ratio is greater than 10, and the organic conjugated micro-molecules have a good application prospect in n-type OFET devices.
Isothiazole derivatives as GPR120 agonists for the treatment of type II diabetes
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Page/Page column 141, (2015/07/07)
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, G, and Q are defined herein.
ISOTHIAZOLE DERIVATIVES AS GPR120 AGONISTS FOR THE TREATMENT OF TYPE II DIABETES
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Page/Page column 161, (2015/11/02)
Disclosed are compounds, compositions and methods for treating of disorders that are affected by the modulation of the GPR120 receptor. Such compounds are represented by Formula (I) as follows: wherein R1, G, and Q are defined herein.
