180302-54-9Relevant academic research and scientific papers
4-Aryl/cycloalkyl-5-phenyloxazole derivatives as selective COX-2 inhibitors
Hashimoto, Hiromasa,Maeda, Kimiya,Ozawa, Koichi,Haruta, Jun-Ichi,Wakitani, Korekiyo
, p. 65 - 68 (2007/10/03)
A series of 4-aryl/cycloalkyl-5-phenyloxazole derivatives was synthesized and evaluated for their ability to inhibit cyclooxygenase-2 (COX-2) and cyclooxygenase-1 (COX-1). These compounds were found to be potent and selective COX-2 inhibitors.
Oxazole derivatives and use thereof
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, (2008/06/13)
Oxazole derivatives of the formula (I) STR1 wherein one of R and R1 is a methylsulfonylphenyl, an aminosulfonyl-phenyl or an alkylaminosulfonylphenyl, and the other is a cycloalkyl having 5 to 7 carbon atoms which is optionally substituted by lower alkyl, a thienyl optionally substituted by lower alkyl or halogen atom or a furanyl optionally substituted by lower alkyl or halogen atom, and R2 is a lower alkyl, and pharmaceutically acceptable salts thereof. The oxazole derivatives and pharmaceutically acceptable salts thereof have superior antipyretic action, analgesic action, anti-inflammatory action, and particularly, selective inhibitory action on cyclooxygenase-2 (COX-2), and are expected to be useful as an antipyretic agent, an analgesic agent and an anti-inflammatory agent with less side-effects such as disorders in the digestive tract.
