180320-55-2

Upstream product

• 138509-45-2 4-bromo-2-cyclopentyloxyanisole 
• 264143-53-5 8-bromovinylidene-1,4-dioxa-spiro[4.5]decane 
• 90-05-1 2-methoxy-phenol 
• 180320-54-1 4-(3-cyclopentyloxy-4-methoxyphenyl)-1,1-(ethylenedioxy)-4-formylcyclohexane 
• 27491-70-9 dimethyl diazomethylphosphonate 
• 37942-01-1 5-bromo-2-methoxyphenol 
• 31083-15-5 2-Methoxyphenyltrifluoracetat 
• 137-43-9 Cyclopentyl bromide 

Downstream Products

• 154284-75-0 trans-?4-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethynyl-cyclohexan-1-ol 
• 181220-58-6 4-(2-[4-carbomethoxymethyloxyphenyl]ethynyl)-4-(3-cyclopentyloxy-4-methoxyphenyl)-1,1-(ethylenedioxy)cyclohexane 
• 181220-56-4 4-(3-cyclopentyloxy-4-methoxyphenyl)-1,1-(ethylenedioxy)-4-(2-[4-(1-piperidinocarbonylmethoxy)phenyl]ethynyl)cyclohexane 
• 181220-51-9 4-(3-cyclopentyloxy-4-methoxyphenyl)-4-(2-[4-(2-hydroxyethan-1-oxy)phenyl]ethynyl)-1,1-(ethylenedioxy)cyclohexane 
• 153587-32-7 4-(3-cyclopentyloxy-4-methoxyphenyl)-4-ethynylcyclohexan-1-one 

Relevant academic research and scientific papers

Synthesis of SB 222618. A potential PDE IV inhibitor

PDE IV inhibitor SB 222618 was prepared by regioselective S(N)2' addition of 9 to bromoallene 6a followed by a stereoselective borane reduction of 4 to afford 2 which by a palladium mediated coupling with 3, delivered SB 222618 (1) in good yield. (C) 2000 Elsevier Science Ltd.

4,4-(disubstituted) cyclohexan-1-one monomers and related compounds

This invention relates to derivatives of 4,4-(disubstituted)cyclohexan-1-ones and related compounds which are useful for treating allergic and inflammatory diseases.