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Tezosentan is a potent dual endothelin (ETA/ETB) receptor antagonist that has been optimized from Bosentan (B675900). It is a pharmaceutical compound designed to target and block the action of endothelin, a potent vasoconstrictor peptide involved in various physiological processes, including the regulation of blood pressure and vascular tone.
Used in Pharmaceutical Industry:
Tezosentan is used as a therapeutic agent for the treatment of congestive heart failure. It helps to improve the symptoms and outcomes of patients suffering from this condition by blocking the effects of endothelin, which can lead to the constriction of blood vessels and increased pressure on the heart. This action results in reduced afterload and improved cardiac function, providing relief to patients with congestive heart failure.

180384-57-0

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180384-57-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 180384-57-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,3,8 and 4 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 180384-57:
(8*1)+(7*8)+(6*0)+(5*3)+(4*8)+(3*4)+(2*5)+(1*7)=140
140 % 10 = 0
So 180384-57-0 is a valid CAS Registry Number.
InChI:InChI=1/C27H27N9O6S/c1-16(2)18-8-9-22(29-15-18)43(38,39)34-26-23(42-21-7-5-4-6-20(21)40-3)27(41-13-12-37)31-24(30-26)17-10-11-28-19(14-17)25-32-35-36-33-25/h4-11,14-16,37H,12-13H2,1-3H3,(H,30,31,34)(H,32,33,35,36)

180384-57-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-[2-(2H-tetrazol-5-yl)pyridin-4-yl]pyrimidin-4-yl]-5-propan-2-ylpyridine-2-sulfonamide

1.2 Other means of identification

Product number -
Other names Tezosentan [INN]

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:180384-57-0 SDS

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