180399-40-0

Basic information

• Product Name: 2-(5-Diethylamino-4-phenyl-4,5-dihydro-[1,2,3]triazol-1-yl)-benzonitrile
• CAS NO: 180399-40-0
• Molecular Weight: 319.409
• Mol File: 180399-40-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(5-Diethylamino-4-phenyl-4,5-dihydro-[1,2,3]triazol-1-yl)-benzonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(5-Diethylamino-4-phenyl-4,5-dihydro-[1,2,3]triazol-1-yl)-benzonitrile(180399-40-0)
• EPA Substance Registry System: 2-(5-Diethylamino-4-phenyl-4,5-dihydro-[1,2,3]triazol-1-yl)-benzonitrile(180399-40-0)

Safety Data

• Hazardous Substances Data: 180399-40-0(Hazardous Substances Data)

Upstream product

• 31656-77-6 2-azidobenzonitrile 
• 122-78-1 phenylacetaldehyde 
• 109-89-7 diethylamine 

Relevant articles and documents

v-Triazolines. Part 37. Rearrangement reactions of 5-amino-1-(2-formyl-, -benzoyl-, -cyano-aryl)-v-triazolines: New synthesis of 2-amino- and 2,4-diamino-quinolines and 2,4-diamino-1,7-naphthyridines

2-Aminoquinolines 4 were obtained in an one-pot reaction from arylacetaldehydes 1, secondary amines 2 and aryl azides 3 in refluxing benzene or xylene. 2,4-Diaminoquinolines and 2,4-diamino-1,7-naphthyridines 9 were prepared by heating arylacetaldehydes 1 with secondary amines 2 and aryl or pyridyl azides 8 and reaction with bases. Reaction intermediates were shown in certain cases to be 5-amino-v-triazolines 5 and 10 undergoing thermal rearrangement to amidines 7 and 11 followed by intramolecular base-catalysed cyclocondensation.