1805-67-0Relevant articles and documents
DESIGN and SYNTHESIS of 1,3-BIS(3-(TRIFLUOROMETHYL)- DIAZIRIN-3-YL)PHENYLALANINE for EFFICIENT PHOTOCROSS- LINKING
Hashimoto, Makoto,Murai, Yuta,Tachrim, Zetryana Puteri,Yoshida, Takuma
, p. 167 - 177 (2022/01/08)
Photoreactive a-amino acids are powerful chemical tools for elucidating interactions in protein networks. Typically, photophores are required for stability and generation of high-reactive species. Additionally, orientation of photophores is one of the significant issues for performing photoaffinity labeling. Therefore, we rationally designed a bis-diazirinyl-phenylalanine for which photocross- linking efficiency could be increased. In this study, we synthesized a new 1,3-bis(3-(trifluoromethyl)diazirin-3-yl)phenylalanine and demonstrated further study in terms of photoactivation.
Preparation method for synthesizing aryl aldehyde compounds by reducing aryl secondary amide or aryl secondary amide derivative through phenylsilane
-
Paragraph 0057-0061, (2021/11/10)
The invention provides a preparation method for synthesizing aryl aldehyde compounds by reducing an aryl secondary amide or aryl secondary amide derivative through phenylsilane. In an inert atmosphere, the aryl secondary amide or an aryl secondary amide derivative is used as a raw material, phenylsilane is used as a reducing agent, 1, 4-dioxane or tetrahydrofuran or diethyl ether is used as a solvent, under the action of isopropyl magnesium chloride, a reaction is performed for 12-48 h at 40-70 DEG C, quenching, separating and purification are performed after the reaction is completed, and the aryl aldehyde product is obtained. The whole preparation process realizes one-step conversion from aryl secondary amide to aryl aldehyde, has the advantages of low cost, mild reaction conditions and high reaction yield, and avoids the use of high-temperature harsh conditions and high-cost noble metal catalysts.
AMINOGUANIDINE HYDRAZONES AS RETROMER STABILIZERS USEFUL FOR TREATING NEUROLOGICAL DISEASES
-
Page/Page column 21; 46; 50, (2020/10/20)
The present invention relates to novel aminoguanidine hydrazone-derivatives of Formula (I) which are effective as retromer stabilizers and useful as neuroprotecting drugs. The invention also relates to pharmaceutical compositions comprising the compounds and their use in therapy and diagnostic.
Construction of hexanuclear macrocycles by a coupling strategy from polyfunctionalized bis(terpyridines)
Eryazici, Ibrahim,Newkome, George R.
scheme or table, p. 345 - 357 (2009/06/21)
The construction of a heteronuclear (Ru4Fe2) hexameric metallomacrocycle with methyl- and carbonyl-functionalized bis(terpyridyl) moieties was achieved by a self-assembly of a dinuclear trimer, which was prepared in high yield via Pd
5-Methylisophthalaldehyde (Uvitaldehyde) from Acyclic Unsaturated Alcohols under Vilsmeier Reaction Conditions
Sreenivasulu, M.,Rao, M. Suresh Chander,Rao, G. S. Krishna
, p. 173 - 174 (2007/10/02)
The Vilsmeier reaction on the acyclic unsaturated alcohols (II-VI) leads to a common product which has been characterized as 5-methylisophthalaldehyde (uvitaldehyde) (IX).The yield of IX varies from 22-35percent depending on the substrate.
Conversion of 1,4-Dihydrobenzoic Acids to Polyformylbenzenes under Vilsmeier Reaction Conditions
Raju, B.,Krishna Rao, G. S.
, p. 197 - 199 (2007/10/02)
1,4-Dihydrobenzoic acids 1a-e are converted by a one-pot reaction to benzene- mono-, di- and tricarboxaldehydes under Vilsmeier reaction conditions in yields ranging from 6 to 65percent.The same methodology also serves to give naphthalene-1,3-dicarboxaldehyde (2f) from 1,4-dihydro-1-naphthoic acid (1f) in 91percent yield.