17649-58-0Relevant articles and documents
Microporous Cyclen-Based Octacarboxylate Hydrogen-Bonded Organic Framework Exhibiting Selective Gas Adsorption
Stackhouse, Chavis,Ren, Junyu,Shan, Chuan,Nafady, Ayman,Al-Enizi, Abdullah M.,Ubaidullah, Mohd,Niu, Zheng,Ma, Shengqian
, p. 6377 - 6380 (2019)
A microporous hydrogen-bonded organic framework (HOF) was successfully prepared by a cyclen-based octacarboxylate ligand H8tacnip-Zn. The obtained three-dimensional structure presents a periodic double-layer unit that stacks to form a one-dimensional channel that buttresses discrete cavities (~5.6 × 5.6 ?2). From the single crystal structure, the macrocycle-bound metal ion was proven to greatly enhance the rigidity of the cyclen-based ligand while adjusting the direction of the carboxyl groups. The indelible porosity of degassed HOF was elucidated by CO2 sorption and selective gas adsorption. This work provides facile access to construct more porous HOFs based on a cyclen unit.
Efficient Gene Delivery Based on Guanidyl-Nucleic Acid Molecular Interactions
Wang, Dongli,Song, Jie,Wang, Jing,Zhang, Zhiyi,Shen, Qing,Wang, Jun,Guo, Haiyan,Wang, Ruifeng,Xie, Cao,Lu, Weiyue,Liu, Min
, (2020)
Low transfection efficacy of non-viral gene vectors restricts their applications. In this paper, N1,N3-dicarbamimidoyl-5-methylisophthalamide (BGG) is designed as a functional group, in which two guanidyls are located at the meta positions of an aryl ring. BGG is conjugated with PAMAM G5 (G5-BGG) and G5-BGG/DNA complex is dispersed into a polyvinyl alcohol (PVA) hydrogel for local injection. Molecular docking, NMR, IR and Isothermal titration calorimetry (ITC) experiments demonstrate that G5-BGG has multiple molecular interactions with nucleic acids, which yield high binding affinity toward nucleic acids. Interestingly, the in vitro transfection efficiency and serum stability of G5-BGG are significantly improved when the BGG modification ratio is just one. The integrated G5-BGG/DNA complex is released from a PVA hydrogel sustainably, crosses the cell membrane and escapes from endosome/lysosome. After local injection only once, these features of the G5-BGG/DNA-loaded PVA hydrogel are found to improve antitumor efficiency in vivo, and antitumor efficiency is significantly better than PEI 25K. The results confirm that BGG is a potential group for developing non-viral gene vectors with high transfection efficacy.
Schenker,Druey
, p. 1344,1350 (1962)
In situ generation of functionality in a reactive haloalkane-based ligand for the design of new porous coordination polymers
Kanoo, Prakash,Matsuda, Ryotaro,Sato, Hiroshi,Li, Liangchun,Jeon, Hyung Joon,Kitagawa, Susumu
, p. 10735 - 10737 (2013)
Herein, we report new porous coordination polymers (PCPs) via a facile synthetic approach called "in situ generation of functionality in the ligand". Upon a synthetic process of PCPs, a neutral (-CH2OH) or a cationic functionality (-CH2-[4,4′-bipyridine]+) was generated on a isophthalate ligand from a reactive haloalkane (-CH 2Br) moiety, affording two new PCPs. The PCPs have two-dimensional layered structures with large potential solvent-accessible voids for CO 2 adsorption.
FLOW CHEMISTRY SYNTHESIS OF ISOCYANATES
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Paragraph 0175; 0186-0187; 0303-0305, (2021/06/22)
The disclosure provides, inter alia, safe and environmentally-friendly methods, such as flow chemistry, to synthesize isocyanates, such as methylene diphenyl diisocyanate, toluene diisocyanate, hexamethylene diisocyanate, isophorone diisocyanate, and tetramethylxylene diisocyanate.