1805115-08-5

Upstream product

• 2646-83-5 3,3,4,4-tetrafluorocyclohexene 
• 36556-47-5 3-chloro-1,2-difluorobenzene 
• 169468-83-1 2-chloro-3,4-difluoro-1-nitrobenzene 
• 211693-73-1 2-amino-3,4-difluoronitro-benzene 
• 959939-24-3 3-amino-2-fluoro-4-nitrophenol 

Relevant academic research and scientific papers

Synthesis of fluorinated halonitrobenzenes and halonitrophenols using tetrafluoroethylene and buta-1,3-dienes as starting building blocks

The gas-phase copyrolysis of tetrafluoroethylene with buta-1,3-diene in a flow reactor at 495–505 °C produces 3,3,4,4-tetrafluorocyclohex-1-ene, which selectively converted to 1,2-difluorobenzene or 1-chloro-2,3-difluorobenzene. The latter can be converted to 2-chloro-3,4-difluoronitrobenzene, 2,3,4-trifluoronitrobenzene, 2,3-difluoro-6-nitrophenol, or 2-chloro-3-fluoro-4-nitrophenol via nitration, fluorodechlorination, and hydrolysis reactions.

TYROSINE KINASE INHIBITOR AND PHARMACEUTICAL COMPOSITION COMPRISING SAME

The present invention relates to a tyrosine kinase inhibitor and a pharmaceutical composition comprising same. The tyrosine kinase inhibitor of the present invention has the structures as shown in the following formula (I) or (II):