180519-09-9

Basic information

• Product Name: 3-(CHLOROMETHYL)-1,5-DIMETHYL-1H-PYRAZOLE
• Synonyms: 3-(CHLOROMETHYL)-1,5-DIMETHYL-1H-PYRAZOLE;3-(Chloromethyl)-1,5-dimethyl-1H-pyrazole 97%;3-(Chloromethyl)-1,5-dimethyl-1h-pyrazole ,97%
• CAS NO: 180519-09-9
• Molecular Formula: C6H9ClN2
• Molecular Weight: 144.6
• Mol File: 180519-09-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 63 °C
• Boiling Point: 225.8°Cat760mmHg
• Flash Point: 90.4°C
• Appearance: /
• Density: 1.17g/cm³
• Vapor Pressure: 0.127mmHg at 25°C
• Refractive Index: 1.542
• CAS DataBase Reference: 3-(CHLOROMETHYL)-1,5-DIMETHYL-1H-PYRAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-(CHLOROMETHYL)-1,5-DIMETHYL-1H-PYRAZOLE(180519-09-9)
• EPA Substance Registry System: 3-(CHLOROMETHYL)-1,5-DIMETHYL-1H-PYRAZOLE(180519-09-9)

Safety Data

• Hazard Codes: C
• Statements: 20/21/22-58-52
• Safety Statements: 16-3/7-36/37
• Hazardous Substances Data: 180519-09-9(Hazardous Substances Data)

Usage

Chemical Properties

White solid

InChI:InChI=1/C6H9ClN2/c1-5-3-6(4-7)8-9(5)2/h3H,4H2,1-2H3

Upstream product

• 4027-57-0 ethyl 5-methyl-1H-pyrazole-3-carboxylate 
• 153912-60-8 (1,5-dimethyl-1H-pyrazol-3-yl)methanol 
• 615-79-2 ethyl 2,4-diketopentanoate 
• 5744-51-4 ethyl 1,5-dimethyl-1H-pyrazole-3-carboxylate 

Downstream Products

• 1184869-53-1 (S)-benzofuran-5-ylmethyl 1-(diisobutylamino)-3-(4-((1,5-dimethyl-1H-pyrazol-3-yl)methoxy)phenyl)-1-oxopropan-2-ylcarbamate 

Relevant articles and documents

Pyrazole functionalized n-heterocyclic carbene ruthenium compound with anticancer activity and preparation method and application thereof

The invention discloses a pyrazole functionalized n-heterocyclic carbene ruthenium compound with anticancer activity and a preparation method and application thereof. The pyrazole functionalized n-heterocyclic carbene ruthenium compound is prepared by using 5-methyl-1-hydrogen-pyrazole ethyl formate through alkylation, reduction, chlorination, salt formation and metal exchange reaction, and the general formula of the pyrazole functionalized n-heterocyclic carbene ruthenium compound is [LRu(p-cymene)Cl](X) (L=pyrazole functionalized n-heterocyclic carbene ligand, and X is anions). In the cytotoxicity test of breast cancer cells (Bcap-37), intestinal cancer cells (LoVo), gastric cancer cells (SCG7901) and cisplatin-resistant gastric cancer cells (SCG7901-R), the n-heterocyclic carbene ruthenium compound can effectively inhibit cancer cell division and reproduction. The n-heterocyclic carbene ruthenium compound is variable in structure, convenient to synthesize, stable in performance, environmentally friendly, capable of stably existing in air for a long time, and promising in application prospect of pharmaceutical industry and fine chemical engineering industry.

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