180519-69-1Relevant academic research and scientific papers
New approaches to the synthesis of functionally substituted pyrido[3′,2′:4,5]thieno[3,2-b]pyridines and the structure of the products obtained
Ivanov,Artemov,Rodinovskaya,Shestopalov,Nesterov,Struchkov,Litvinov
, p. 105 - 111 (1996)
Substituted pyrido[3′,2′:4,5]thieno[3,2-b]pyridines were obtained by the reaction of 3-amino-2-benzoylthieno[2,3-b]pyridines with malononitrile and the reaction of 3-cyanopyridine-2(1H)-thiones with 2-aryl-3-bromo-1,1-dicyanopropene. 2-Amino-4-(4-bromophe
2-Bromo-1-arylethylidenemalononitriles - Convenient reagents for the regioselective synthesis of fused pyridines
Artyomov, Vasilii A.,Ivanov, Vladimir L.,Shestopalov, Anatolii M.,Litvinov, Victor P.
, p. 13351 - 13360 (2007/10/03)
2-Bromo-1-arylethylidenemalononitriles react with conjugated thiolaronitriles to give products of regioselective S alkylation that can be subsequently involved in the Thorpe reaction. Resulting enaminoacrylonitriles form pyridine ring under base catalysis yielding thienodipyridines. According to this common scheme, functionally substituted thieno[3,2-b]pyridines, thiazolo[4,5-b]pyridines, thieno[3,2-b-4,5-h']dipyridines, their hydrogenated analogues, and pyrido[2',3':4,5]thieno[2.3-d]pyrimidine were synthesized.
