180532-48-3Relevant academic research and scientific papers
Novel histone deacetylase inhibitors: N-hydroxycarboxamides possessing a terminal bicyclic aryl group
Uesato, Shinichi,Kitagawa, Manabu,Nagaoka, Yasuo,Maeda, Taishi,Kuwajima, Hiroshi,Yamori, Takao
, p. 1347 - 1349 (2007/10/03)
Utilizing tranexamic acid as a starting material, a series of N-hydroxycarboxamides were synthesized in order to seek new histone deacetylase (HDAC) inhibitors. Further structure optimization involving the replacement of the 1,4-cyclohexylene group with t
Piperazine derivatives, medicaments comprising these compounds, their use and processes for their preparation
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, (2008/06/13)
The present invention relates to piperazine derivatives of the general formula STR1 in which Ra, Y1 to Y3 and E are defined herein, tautomers thereof, stereoisomers thereof, including their mixtures, and salts thereof, and in particular physiologically tolerated salts thereof with inorganic or organic acids or bases. These compounds have valuable pharmacological properties, such as aggregation-inhibiting activity. This invention also relates to medicaments comprising these compounds and to processes for the preparation of these compounds.
