180589-07-5Relevant academic research and scientific papers
Synthesis of C2 symmetric potential inhibitors of HIV-1 protease from D-mannitol
Niklasson, Gunilla,Kvarnstroem, Ingemar,Classon, Bjoern,Samuelsson, Bertil,Nillroth, Ulrika,Danielson, Helena,Karlen, Anders,Hallberg, Anders
, p. 555 - 569 (2007/10/03)
D-Mannitol was used as precursor for the synthesis of acyclic C2 symmetric potential HIV-1 protease inhibitors. The 1-and 6-hydroxy groups of D-mannitol were substituted by -NHBoc, -NHValZ, -SAr, -SOAr and -SO2Ar and the 2-and 5-hydroxy groups were benzylated. In some products one of the central hydroxyl groups was either inverted or deoxygenated. Despite a close structural similarity to previously published inhibitors none of the products showed significant inhibitory activity against HIV-1 protease.
