1806-32-2Relevant articles and documents
Preparation method of 4-tert-butyl-2([alpha]-methylbenzyl)phenol
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Paragraph 0010; 0015; 0026-0029, (2021/03/31)
The invention discloses a preparation method of 4-tert-butyl-2([alpha]-methylbenzyl)phenol. The preparation method comprises the following steps: step A, washing resin with water, adding the resin into a beaker containing 1%-8% of an acidic solution in a ratio of 300g: 1L, stirring and acidifying for 26 hours, filtering to obtain resin, washing the resin with water to be neutral, repeating for 35times, and drying the obtained resin in a constant-temperature drying oven at the temperature of less than or equal to 60 DEG C to obtain dried resin; and storing the dried resin by using a dryer. According to the preparation method of the 4-tert-butyl-2([alpha]-methylbenzyl)phenol, resin is adopted as a catalyst, the resin is easily separated from reactants, and complex post-treatment is not needed; the catalytic effect is good, the catalytic selectivity is high, the resin can be repeatedly used, and continuation is easy to realize; equipment is not corroded, and the requirement for equipmentmaterials is not high; little waste is generated in the reaction process, and waste treatment is simplified; and meanwhile, the method has the advantages of low energy consumption, simple operation,environmental protection and the like.
Preparation method of alkylphenol compounds
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Paragraph 0055-0057, (2020/04/29)
The invention provides a method for preparing alkylphenol compounds from phenol compounds and olefin. The method has the characteristics of cheap and easily available raw materials, simple reaction system, simplicity in reaction operation, wide substrate range, compatibility with groups such as CHO and COOH, and excellent regioselectivity, generates no overalkylation products due to only alkylation of phenol and no influence on common aryl groups, and can be used for modifying drug intermediates. The method mainly solves the problems of harsh conditions such as use of a strong Lewis catalyst,poor functional group compatibility, poor selectivity, need of prefabrication of a catalyst material and the like in other methods, and H3PO3 plays a dual role in the same system, can promote alkene to generate carbocations, and also can inhibit isomerization of phenol.
HBF4- and AgBF4-Catalyzed ortho-Alkylation of Diarylamines and Phenols
Rank, Christian K.,?zkaya, Bünyamin,Patureau, Frederic W.
supporting information, p. 6830 - 6834 (2019/09/12)
A silver-tetrafluoroborate- or HBF4-catalyzed ortho-alkylation reaction of phenols and diarylamines with styrenes has been explored. A broad substrate scope is presented as well as mechanistic experiments and discussion.