180633-66-3Relevant academic research and scientific papers
Convenient access to bis-indole alkaloids. Application to the synthesis of?topsentins
Mal, Sajal K.,Bohé, Luis,Achab, Sa?d
, p. 5904 - 5914 (2008/12/20)
Topsentins and related bis-indole alkaloids may be efficiently synthesized through an addition/oxidation sequence leading to 2-(3-indolylcarbonyl)-imidazole derivatives followed by a Pd-catalyzed heteroarylation with the appropriate 3-stannylindoles.
Low molecular weight indole fragments as IMPDH inhibitors
Beevers, Rebekah E.,Buckley, George M.,Davies, Natasha,Fraser, Joanne L.,Galvin, Francis C.,Hannah, Duncan R.,Haughan, Alan F.,Jenkins, Kerry,Mack, Stephen R.,Pitt, William R.,Ratcliffe, Andrew J.,Richard, Marianna D.,Sabin, Verity,Sharpe, Andrew,Williams, Sophie C.
, p. 2535 - 2538 (2007/10/03)
The study of non-oxazole containing indole fragments as inhibitors of inosine monophosphate dehydrogenase (IMPDH) is described. The synthesis and in vitro inhibitory values for IMPDH II are discussed.
A three-component coupling approach to the marine bis-indole alkaloids: Topsentin, deoxytopsentin and bromotopsentin
Achab, Said
, p. 5503 - 5506 (2007/10/03)
The total syntheses of three marine bis-indole alkaloids (1, 2, 4) of the topsentin family together with the synthesis of unnatural deoxybromotopsentin (33) are described. Key elements include, a 1,2-addition-oxidation sequence to construct the bis-hetero
