18065-03-7

Usage

Structure

Phenylethanone backbone with a nitrophenyl ether group attached to the second carbon atom.

Usage

Organic synthesis, pharmaceutical research, potential medicinal properties.

Studied for

Anti-inflammatory and analgesic effects, possible applications in the development of new drugs for various medical conditions.

Safety

Handle with caution, may have harmful effects if not properly used and stored.

Upstream product

• 100-02-7 4-nitro-phenol 
• 532-27-4 1-chloroacetophenone 
• 70-11-1 α-bromoacetophenone 
• 25917-49-1 1-(4-chlorophenyl)-2-(p-tolylsulfonyloxy)ethanone 
• 71-43-2 benzene 
• 824-78-2 4-nitrophenol sodium salt 

Downstream Products

• 92161-13-2 <4-Nitro-phenyl>-<μ-brom-phenacyl>-ether 
• 95702-67-3 (2-Phenyl-1-benzoyl-vinyl)-(4-nitro-phenyl)-ether 
• 94873-24-2 (2-(2-Nitro-phenyl)-1-benzoyl-vinyl)-(4-nitro-phenyl)-ether 
• 100-02-7 4-nitro-phenol 
• 65-85-0 benzoic acid 
• 92438-32-9 <4-Nitro-phenoxy>-benzoyl-acetonitril 
• 100149-00-6 ω,ω-Bis-(4-nitro-phenoxy)-acetophenon 
• 92856-55-8 ω-(4-Nitro-phenoxy)-ω-acetoxy-acetophenon 
• 97498-89-0 ω-Ethoxy-ω-(p-nitro-phenoxy)-acetophenon 
• 129330-22-9 7-(4-Nitro-phenoxy)-3,6-diphenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 129330-15-0 3-Ethyl-7-(4-nitro-phenoxy)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 
• 129330-09-2 3-Methyl-7-(4-nitro-phenoxy)-6-phenyl-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazine 

Relevant academic research and scientific papers

Synthesis, characterization, and third-order nonlinear optical properties of a new neolignane analogue

Recently, a wide number of pharmacological activities, such as anti-leishmanial, antioxidant and antitumor, have been discovered for neolignane analogues. To provide a view of the non-linear optical behavior of the third order of the crystal 2-(4-nitrophe

Synthesis of benzofurans from the cyclodehydration of α-phenoxy ketones mediated by Eaton’s reagent

Cyclodehydration of α-phenoxy ketones promoted by Eaton’s reagent (phosphorus pentoxide–methanesulfonic acid) is used to prepare 3-substituted or 2,3-disubstituted benzofurans with moderate to excellent yields under mild conditions. The method provides a facile access to benzofurans from readily available starting materials such as phenols and α-bromo ketones. The reaction is highly efficient, which is attributed to the good reactivity and fluidity of Eaton’s reagent. The reaction can be applied to prepare naphthofurans, furanocoumarins, benzothiophenes, and benzopyrans.

Synthesis, characterization and in vitro anticancer activity of novel 8,4’-oxyneolignan analogues

Neolignans are a class of natural products with a wide range of biological effects. These substances are of great synthetic and biological interest, especially in searching for novel anticancer agents. In this paper, we report the synthesis of a new subclass of 8,4’-oxyneolignan analogues (Β-ketoethers and Β-ketoesters) and their cell viability assay on twenty four different cancer cells, among leukemias and carcinomas. Three compounds inhibited the growth of most human cancer cells. 2-Oxo-2-phenylethyl(2E)-3-[4-(2-oxo-2-phenylethoxy) phenyl]prop-2-enoate showed an antiproliferative activity superior to doxorubicin for U-87, U-138 MG and H1299 cell types and (E)-2-oxo-2-phenylethyl 3-(3-methoxy-4-(2-oxo-2-phenylethoxy)phenyl)acrylate was found to be very selective, demonstrating a growth inhibition of 92.0% against KG-1 cells. Furthermore, 1-oxo-1-phenylpropan-2-yl cinnamate exhibited significant inhibition activity in a range of 52.2 to 91.2% against twelve kinds of leukemia cell lines, revealing excellent results and very comparable to the reference drug.

α-(4-Nitro Phenoxy) chalcones as synthons for cis-(±)-1,5- benzothiazepines

α-(4-Nitro Phenoxy) chalcones, V have been utilized as intermediate for the synthesis of some new cis- (±)-2-aryl-3-(4-nitro phenoxy)-4-phenyl-1,5- benzothiazepine VI by cycloconden-sation of 2-amino thiophenol in the presence of mild base.

Three-step synthesis of an array of substituted benzofurans using polymer-supported reagents

An efficient combinatorial route to substituted 3-phenyl-benzofurans, is achieved by the bromination of acetophenones to α-bromoacetophenones by polymer-supported pyridinium bromide perbromide (PSPBP). The subsequent clean substitution of the obtained bromides by phenols using 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD-P) and cyclodehydration of the resulting α-phenoxyacetophenones using Amberlyst 15, affords pure products without the need for any chromatographic purification step.

A simple method for the preparation of aryl phenacyl ether in micellar medium: Part I

Aryl phenacyl ethers have been prepared by the micellar catalysed reaction of phenacyl bromide with equimolar mixture of phenol(s)- triethylamine in 70% methanol(v/v) 30 °C. The ethers have been characterised on the basis of their IR, 1H and s

ARYLOXYMETHYL-RADICAL FORMATION ENTHALPIES

Enthalpies of formation have been determined for six substituted phenoxymethyl radicals.Donor substituents exert a stabilizing effect on the radical center in each case, and acceptor ones have a destabilizing effect.