180684-36-0

Upstream product

• 71413-14-4 alpha-N-(t-butoxycarbonyl)-N^g-nitroargininal 
• 2188-18-3 N^α-t-butoxycarbonyl-N^ω-nitro-L-arginine 
• 186261-75-6 Boc-Arg(NO₂)-H 
• 150908-38-6 1-t-butoxycarbonyl-semicarbazidyl-4-diphenylmethane 

Relevant academic research and scientific papers

Synthesis and biological activity of P2-P4 azapeptidomimetic P1-argininal and P1-ketoargininamide derivatives: A novel class of serine protease inhibitors

Molecular modeling and topographic considerations of the thrombin-specific sequences Boc-Asp-Pro-Arg-TS or Ac-d-Phe-Pro-Arg-TS (TS = transition state analog electrophilic center) and related scaffolds led to the design of novel P2-P4-azapeptidomimetic P1-argininal and P1-ketoargininamide derivatives (3a-j). The synthesis and biological activity of these potential serine protease inhibitors are presented.

Improved synthesis of arginine peptide aldehydes

An improved method for the synthesis of peptide argininals by the use of a new aldehyde protecting group (diphenylmethyl semicarbazide) is reported.