180691-45-6

Upstream product

• 1131-18-6 1-Phenyl-3-methyl-5-aminopyrazole 
• 122-01-0 4-chloro-benzoyl chloride 
• 4231-70-3 p-chlorobenzoyl-1H-1,2,3-benzotriazole 

Downstream Products

• 633336-51-3 (3-methyl-4-morpholin-4-yl-1,6-diphenyl-1,4-dihydro-5-oxa-1,2,7-triaza-4λ⁵-phospha-inden-4-ylidene)-phenyl-amine 
• 633336-50-2 (2-chloro-phenyl)-[6-(4-chloro-phenyl)-3-methyl-1-phenyl-1H-5-oxa-1,2,7-triaza-4-phospha-inden-4-yl]-amine 
• 633336-49-9 [6-(4-chloro-phenyl)-3-methyl-1-phenyl-1H-5-oxa-1,2,7-triaza-4-phospha-inden-4-yl]-phenyl-amine 
• 633336-57-9 C₁₉H₁₉ClN₃O₃P 
• 633336-41-1 4-bromo-6-(4-chloro-phenyl)-3-methyl-1-phenyl-1,4-dihydro-5-oxa-1,2,7-triaza-4-phospha-indene 

Relevant academic research and scientific papers

One-step synthesis, crystallographic studies and antimicrobial activity of new 4-diazopyrazole derivatives

A number of new 4-diazopyrazole derivatives were prepared by the reaction of 1-R-3-methyl-5(R1-substituted)benzamidopyrazoles with a sevenfold excess of nitrous acid in acetic medium. The compounds were tested for activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Staphylococcus epidermidis, Streptococcus faecalis, Listeria monocytogenes, Candida albicans, Candida tropicalis and Paecilomyces varioti. The highest microbial susceptibility was shown by Gram-positive bacteria, with minimum inhibitory concentrations (MIC) in the range 0.5-12.5 μg/mL. For S aureus the R1 substituents were screened utilizing the Topliss operational scheme. The 4-nitro group was found to be the best substituent. We also tested the compounds 41,o,p, found to be the most active in the test against S aureus ATCC 25923, on ten clinical S aureus strains, five of which were sensitive and five resistant to methicillin. The above compounds were active in the range 2-8 μg/mL against methicillin-resistant S aureus strains. An X-ray analysis of compounds 4i and 4q is reported.

(α-aminoacyl)amino-substituted heterocycles and related compounds

(Chemical Equation Presented) N-Protected-(aminoacyl)benzotriazoles 1a-e,g,i,j,1a′-c′ convert heterocyclic amines of the following series: thiazoles (3a and 3a′), benzothiazoles (3b and 3b′), benzimidazoles (3c and 3c′), thiadiazoles (3d), pyrimidones (9a