180692-27-7Relevant articles and documents
Amino pyrimidine compound and preparation method and application thereof
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Paragraph 0267; 0270; 0271; 0272, (2018/11/22)
The invention relates to an amino pyrimidine compound and a preparation method and application thereof. The amino pyrimidine compound has a structure as shown in a formula I. The formula is shown in the description. The compound is an inhibitor of an epidermal growth factor receptor (EGFR) kinase. The invention further relates to a medicine composition comprising the compound, a preparation methodand application thereof in preparation of anti-tumor medicines.
SUBSTITUTED ANTHRANILIC AMIDE DERIVATIVES AND METHODS OF USE
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Page 112-113, (2010/02/06)
Selected compounds are effective for prophylaxis and treatment of diseases, such as angiogenesis mediated diseases. The invention encompasses novel compounds, analogs, prodrugs and pharmaceutically acceptable salts thereof, pharmaceutical compositions and methods for prophylaxis and treatment of diseases and other maladies or conditions involving, cancer and the like. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
Structure-activity relationship studies of flavopiridol analogues
Murthi, Krishna K.,Dubay, Marja,McClure, Christopher,Brizuela, Leonardo,Boisclair, Michael D.,Worland, Peter J.,Mansuri, Muzammil M.,Pal, Kollol
, p. 1037 - 1041 (2007/10/03)
Cyclin dependent kinases (CDKs) along with the complementary cyclins form key regulatory checkpoint controls on the cell cycle. Flavopiridol is a synthetic flavone that shows potent and selective cyclin-dependent kinase inhibitory activity. In this paper, we report modifications of the 3-hydroxy-1-methylpiperidinyl (D ring) of flavopiridol and their effect on CDK inhibitory activity. (C) 2000 Elsevier Science. All rights reserved.