180692-68-6Relevant articles and documents
Asymmetric synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W from 4-pentenoic acid
Chatterjee, Bhaskar,Mondal, Dhananjoy,Bera, Smritilekha
, p. 1170 - 1185,16 (2020/09/09)
A flexible and efficient asymmetric route to the synthesis of a 12-membered macrolactone core and a 6-epi analogue of amphidinolide W has been accomplished from commercially available 4-pentenoic acid. The successful generation of stereocenters was achieved by utilizing an Evans' chiral auxiliary-based alkylation and aldol reaction. Other key reactions such as a Julia-Kocienski olefination, Kita's macrolactonization, ring closing metathesis (RCM) reaction, and Yamaguchi's esterification were significant for the construction of the macrolactone cores.
Highly stereoselective approach toward the synthesis of the macrolactone core of amphidinolide W
Mohapatra, Debendra K.,Chatterjee, Bhaskar,Gurjar, Mukund K.
body text, p. 755 - 758 (2009/05/07)
The diastereoselective synthesis of the macrolactone core of amphidinolide W was successfully accomplished using Evans' asymmetric alkylation, Aldol reaction, Julia-Kocienski olefination, and Kita's macrocyclization protocol.
Synthesis of bistramide A
Statsuk, Alexander V.,Liu, Dong,Kozmin, Sergey A.
, p. 9546 - 9547 (2007/10/03)
We have developed an efficient and highly stereocontrolled synthesis of bistramide A, a selective activator of protein kinase C isotype δ. Our synthetic strategy featured a novel bidirectional approach for spiroketal construction based on the ring-opening
