180695-75-4Relevant academic research and scientific papers
4-N-linked-heterocyclic piperidine derivatives with high affinity and selectivity for human dopamine D4 receptors
Moore, Kevin W.,Bonner, Katrine,Jones, Elizabeth A.,Emms, Frances,Leeson, Paul D.,Marwood, Rosemary,Patel, Shil,Patel, Smita,Rowley, Michael,Thomas, Steven,Carling, Robert W.
, p. 1285 - 1290 (1999)
The syntheses of a number of different N-linked heterocyclic pyrazole replacements based on the structure 1 are described (compounds 3-12) as hD4 ligands. After further optimisation the best compound identified was 13 which has high affinity for hD4 (5.2 nM) and >300-fold selectivity for hD4 receptors over hD2 and hD3 receptors.
