180697-46-5Relevant academic research and scientific papers
Piperazine derivatives and methods for the preparation thereof and compositions containing the same
-
, (2008/06/13)
The present invention relates to novel compound of the general formula(I) and acid addition salt thereof. STR1 wherein R1 and R2 are independently hydrogen, C1 -C8 alkyl or optionally substituted C3 -C6 membered cycloalkyl containing C3 -C8 ; R3, R4, R5, R6 and R7 are independently hydrogen, halogen, hydroxy, nitro, C1 -C4 lower ester, C1 -C4 lower alkyl, C1 -C4 lower alkoxy, aryl, arylalkoxy or unsaturated amine; l is an integer of 0-7; m and n are independently an integer of 0-1; W is carbon or nitrogen; X is oxygen, sulfur, optionally substituted imine; Y is nitrogen or oxygen; and Z is hydrogen, C1 -C8 alkoxy, aryloxy, C1 -C4 alkylamine, cycloamine containing N1 -N5 or oxo group. The present compounds of the above formula (I) has no only strong antimumor activities but lower toxicities, and accordingly are expected as novel antitumor agents.
