180713-37-5 Usage
Uses
1. Used in Pharmaceutical Applications:
(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoic acid is used as a ligand for retinoid X receptor (RXR) in the pharmaceutical industry. It acts as an antagonist towards RXR homodimers but as an agonist of heterodimers consisting of RXR and retinoic acid receptor (RAR) or PPARs. This dual action allows the compound to modulate the activity of RXR dimers, which can be beneficial in the treatment of various medical conditions.
2. Used in Anticancer Applications:
In the field of oncology, (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid is employed as an anticancer agent. It has been shown to modulate several oncological signaling pathways, potentially exerting inhibitory effects on tumor growth and progression. Additionally, it may demonstrate synergistic anticancer effects when combined with conventional chemotherapeutic drugs, enhancing chemo-sensitivity and efficacy in resistant cases.
3. Used in Drug Delivery Systems:
To overcome the limitations of (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid, novel drug delivery systems have been developed to enhance its applications and efficacy against cancer cells. Various organic and metallic nanoparticles have been employed as carriers for the delivery of (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoicacid, aiming to improve its delivery, bioavailability, and therapeutic outcomes.
4. Used in the Treatment of Metabolic Disorders:
(2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoic acid is used as a novel RXR:PPARγ agonist, which can decrease glucose levels in vivo. This makes it a potential candidate for the development of treatments for metabolic disorders such as diabetes.
5. Used in the Development of Anti-androgen and Anti-thyroid Agents:
The compound can also be used in compositions comprising anti-androgen and anti-thyroid agents, which may have applications in the treatment of hormone-related disorders.
6. Used in Diagnostic and Treatment Kits for Viral Respiratory Infections:
Furthermore, (2E,4E,6Z)-3-Methyl-7-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-3-propoxy-3-naphthalenyl)-2,4,6-octatrienoic acid can be utilized in the development of kits for the diagnosis and treatment of viral respiratory infections, potentially offering new therapeutic options for patients suffering from such conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 180713-37-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,8,0,7,1 and 3 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 180713-37:
(8*1)+(7*8)+(6*0)+(5*7)+(4*1)+(3*3)+(2*3)+(1*7)=125
125 % 10 = 5
So 180713-37-5 is a valid CAS Registry Number.
InChI:InChI=1/C26H36O3/c1-8-14-29-23-17-22-21(25(4,5)12-13-26(22,6)7)16-20(23)19(3)11-9-10-18(2)15-24(27)28/h9-11,15-17H,8,12-14H2,1-7H3,(H,27,28)/b10-9+,18-15+,19-11-
180713-37-5Relevant academic research and scientific papers
EXPANSION OF RENEWABLE STEM CELL POPULATIONS
-
Paragraph 0510, (2016/05/02)
Ex vivo and in vivo methods of expansion of renewable stem cells, expanded populations of renewable stem cells and their uses.
