180720-86-9Relevant academic research and scientific papers
New phosphoramidite derivatives for the preparation of oligonucleotides containing a hydrazide group in any specified position of the oligonucleotide chain
Antsypovich,Oretskaya,Von Kiedrowski
, p. 2671 - 2681 (2005)
A new versatile method for the preparation of oligonucleotides containing hy drazide groups in any position of the oligonucleotide chain by standard phosphoramidite automated oligonucleotide synthesis is proposed. The method is based on the use of a serie
Novel Reagents Utilizing A Serinol Scaffold For Labeling Synthetic Oligonucleotides
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Page/Page column 4; 9, (2011/04/19)
Novel CE-phosphoramidites and CPG reagents have been synthesized from a serinol backbone. These reagents are useful to introduce functional groups or directly label oligonucleotides. The versatile serinol scaffold allows for labeling at any position (5′ or 3′ termini, or any internal position) during automated DNA synthesis. Multiple labels or functional groups can be achieved by repetitive coupling cycles. Optimal spacer arms and protected label moieties have been specially designed. Further, the natural 3-carbon atom internucleotide phosphate distance is retained when inserted internally.
Synthesis and hybridization properties of sugar-modified oligonucleotides
Sharma, Ashwani K.,Kumar, Pradeep,Gupta, Kailash C.
, p. 3643 - 3649 (2007/10/03)
L-Threoninol-derived acyclic nucleotide monomers were prepared and incorporated into oligonucleotides at preselected positions via phosphoramidite chemistry. Hybridization properties of these modified oligonucleotides with the corresponding natural oligom
Peptide nucleic acids and their phosphonate analogues: Synthesis and hybridization properties
Efimov,Buryakova,Choob,Chakhmakhcheva
, p. 618 - 630 (2007/10/03)
The synthesis of a series of DNA mimics-peptide nucleic acids, phosphonate analogues of peptide nucleic acids, and their hybrids - is described. The preparative synthesis of the corresponding monomers and the solid phase automated synthesis of oligomers-mimics are developed. Modified phosphonate analogues of peptide nucleic acids, in particular, chiral derivatives and those with additional hydroxyl groups in the side chains of the backbone, as well as pyrene derivatives of peptide nucleic acids and their phosphonate analogues, are prepared. The affinity of the resulting oligomers specifically to hybridize to DNA and RNA complementary chains is studied. It is shown that phosphonate analogues of peptide nucleic acids and their hybrids with peptide nucleic acids can form complexes with the DNA and RNA complementary strands, the stability of the complexes increasing in parallel with the increase in the number of peptide nucleic acid residues in the chain of the mimic. This property, along with good water solubility, provides the precondition for further evaluation of these compounds as antisense and antigene agents.
