180744-72-3Relevant academic research and scientific papers
94. Preparation of α,α-dibromocyclobutanones from olefins: A simple procedure for the regioselective functionalization of olefins
Chaumeil, Helene,Le Drian, Claude
, p. 1075 - 1084 (1996)
Dibromoketene is prepared by in-situ Zn dehalogenation of tribromoaoetyl bromide in the presence of POCl3. Under these conditions, the cycloaddition of dibromoketene with olefins 5 yields α,α-dibromocyclobutanones 2, which are cleaved with alko
New ring expansion of cyclobutanones: Synthesis of pyrrolinones, pyrrolidines and pyrroles
Verniest, Guido,Boterberg, Stefaan,Bombeke, Filip,Stevens, Christian V.,De Kimpe, Norbert
, p. 1059 - 1063 (2007/10/03)
2,2-Dichlorocyclobutanones reacted with various amines to give ring opening leading to 4,4-dichlorobutanamides. These compounds proved to be suitable substrates for the synthesis of 3-pyrrolin-2-ones, 2-pyrrolidinones, pyrrolidines and pyrroles.
