180746-12-7Relevant academic research and scientific papers
Palladium-catalyzed direct arylation of methyl sulfoxides with aryl halides
Jia, Tiezheng,Bellomo, Ana,Baina, Kawtar El,Dreher, Spencer D.,Walsh, Patrick J.
supporting information, p. 3740 - 3743 (2013/04/10)
The palladium-catalyzed α-arylation of unactivated sulfoxides has been developed. The weakly acidic α-protons of sulfoxides are reversibly deprotonated by LiOtBu, and a palladium phosphine complex facilitates the arylation. A variety of aryl methyl sulfoxides were coupled with aryl bromides. More challenging coupling partners, such as alkyl methyl sulfoxides (including dimethyl sulfoxide) and aryl chlorides proved to be suitable under the optimized conditions. This method was utilized to synthesize bioactive benzyl sulfoxide intermediates.
Copper-catalyzed asymmetric oxidation of sulfides
O'Mahony, Graham E.,Ford, Alan,Maguire, Anita R.
body text, p. 3288 - 3296 (2012/05/20)
Copper-catalyzed asymmetric sulfoxidation of aryl benzyl and aryl alkyl sulfides, using aqueous hydrogen peroxide as the oxidant, has been investigated. A relationship between the steric effects of the sulfide substituents and the enantioselectivity of th
