18075-42-8

Upstream product

• 18075-41-7 2-allyl-3-hydroxy-4-methoxybenzaldehyde 
• 100-39-0 benzyl bromide 
• 621-59-0 isovanillin 
• 106-95-6 allyl bromide 
• 620-05-3 iodomethylbenzene 
• 18075-40-6 O-allylisovanillin 

Downstream Products

• 374073-60-6 1-[2-allyl-3-(benzyloxy)-4-methoxyphenyl]prop-2-en-1-ol 
• 469898-65-5 3-benzyloxy-4-methoxy-1-(1'-hydroxyethyl)-2-(prop-2'-enyl)benzene 
• 778638-78-1 2-allyl-3-benzyloxy-4-methoxy-1-vinylbenzene 
• 934749-64-1 2-cyano-3-(2-allyl-3-benzyloxy-4-methoxyphenyl)-1-propen-3-ol 
• 934749-69-6 1-benzyloxy-6-cyano-2-methoxynaphthalene 
• 1390647-82-1 4-benzyloxy-9,10-dichloro-3-methoxy-6-methyl-5,6-dihydro-benzo[4,5]imidazo[2,1-a]isoquinoline 
• 1390647-88-7 4-benzyloxy-3-methoxy-6,9,10-trimethyl-5,6-dihydro-benzo[4,5]imidazo[2,1-a]isoquinoline 
• 1390647-76-3 4-benzyloxy-3-methoxy-6-methyl-5,6-dihydro-benzo[4,5]imidazo[2,1-a]isoquinoline 
• 1420804-91-6 8-(benzyloxy)-7-methoxynaphthalen-2-ol 
• 1420805-22-6 3-(benzyloxy)-4-methoxy-2-(2-oxopropyl)benzaldehyde 

Relevant academic research and scientific papers

TBuO 2H/Cu(acac) 2-Mediated Intramolecular Oxidative Lactonization of o -Allyl Arylaldehydes: Synthesis of 1-Oxoisochromans

A concise route for the tBuO 2H/Cu(acac) 2-mediated synthesis of 1-oxoisochromans is described. This includes: (i) oxidation of oxygenated o -allyl arylaldehydes and (ii) sequential intramolecular lactonization of the resulting olefin-containing benzoic acids. A plausible mechanism is proposed and discussed.

CuI Mediated One-Pot Cycloacetalization/Ketalization of o-Carbonyl Allylbenzenes: Synthesis of Benzobicyclo[3.2.1]octane Core

CuI/DMSO-mediated intramolecular cycloacetalization/ketalization of o-carbonyl allylbenzenes has been achieved for constructing [6,6,5]-tricycles having a ketal motif in good yields. The expeditious one-step route provides a three C-O bond formation. The key products with the structural framework of a benzofused dioxabicyclo[3.2.1]octane core have been confirmed by X-ray crystallographic analysis. Synthesis of dihydroisocoumarin has been studied.

Synthesis of 2-hydroxymethyl-2,3-dihydrobenzofurans

A one-pot protocol toward 2-hydroxymethyl-2,3-dihydrobenzofurans (1) starting with oxygenated o-allylbenzaldehydes (3) was described. The facile one-pot process was carried out by the oxidation of o-allylbenzaldehydes (3) with Oxone in the co-solvent of acetone and DMF in the presence of aqueous EDTA solution and then intramolecular ring-closure of the resulting o-allylphenols (2) in acceptable yields.

Synthesis of substituted indenes from isovanillin via claisen rearrangement and ring-closing metathesis

A new synthesis of substituted indenes was studied. Based on Claisen rearrangement,Wittig reaction and ring-closing metathesis (RCM), a series of substituted indenes was synthesized from isovanillin in good yields.

One-pot access to 2-naphthols and benzofurans via the aerobic Wacker-type oxidation/intramolecular aldol cyclization

An aerobic Wacker-type oxidation/intramolecular aldol cyclization synthetic route toward two oxygenated 2-naphthols 3 and benzofurans 4 starting with skeleton 2 with good yields is described. The route has been carried by the one-pot transformation of the regioselective PdCl2/CuCl 2-mediated Wacker oxidative cyclization of skeleton 2 with molecular oxygen under the alkaline methanolic condition. Skeleton 2 was prepared from skeleton 1 in moderate total yields via the known protocol.

Synthesis of dihydrobenzoimidazo[2,1-a]isoquinolines

A one-pot protocol toward several substituted 5,6-dihydrobenzo[4,5] imidazo[2,1-a]isoquinolines 1 starting with 2-allylbenzaldehydes 2 was described. The process was carried out the one-pot condensation/hydroamination reaction of substituted 2-allylbenzaldehydes 2 with 1,2-diaminobenzenes 3 in refluxing toluene in good yields. Skeleton 2 was prepared via one-pot ortho-metalative PhBCl2-mediated double alkylation of hydroxybenzaldehyde 4 with LDA in moderate yields.

Total synthesis of pulverolide: Revision of its structure

A flexible and practical strategy toward the synthesis of rare 2H-furo[3,2-b]benzopyran-2-one skeleton has been developed. With a microwave-assisted cyclization-dehydration as the key transformation, the first total synthesis of pulverolide has been compl

Claisen rearrangement/Baylis-Hillman reaction/ring-closing metathesis as bases for the construction of substituted cyanonaphthalenes

The present paper described how to establish a novel approach for various alkoxycyanonaphthalenes. It was started from isovanillin, and based on the Claisen rearrangement, O-alkylation, the Baylis-Hillman reaction, and ring-closing metathesis in sequence

Syntheses of substituted naphthalenes and naphthols

Syntheses of substituted naphthalenes and naphthols are described. Based on Claisen rearrangement, ring-closing metathesis (RCM), and related reactions, isovanillin was successfully transformed into a series of substituted naphthalenes and naphthols with

Synthesis of substituted indenes from isovanillin via claisen rearrangement and ring-closing metathesis

A new synthesis of substituted indenes was studied. Based on Claisen rearrangement, Wittig reaction and ring-closing metathesis (RCM), a series of substituted indenes was synthesized from isovanillin in good yields.