180790-90-3

Basic information

• Product Name: 4-Pyridinecarbonitrile,2-(methylthio)-(9CI)
• Synonyms: 4-Pyridinecarbonitrile,2-(methylthio)-(9CI);2-(Methylthio)isonicotinonitrile;2-(methylthio)isonicotinonitrile(SALTDATA: FREE)
• CAS NO: 180790-90-3
• Molecular Formula: C₇H₆N₂S
• Molecular Weight: 150.20094
• Product Categories: PYRIDINE
• Mol File: 180790-90-3.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 260.6±25.0 °C(Predicted)
• Appearance: /
• Density: 1.21±0.1 g/cm3(Predicted)
• PKA: 0.27±0.10(Predicted)
• CAS DataBase Reference: 4-Pyridinecarbonitrile,2-(methylthio)-(9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Pyridinecarbonitrile,2-(methylthio)-(9CI)(180790-90-3)
• EPA Substance Registry System: 4-Pyridinecarbonitrile,2-(methylthio)-(9CI)(180790-90-3)

Safety Data

• Hazardous Substances Data: 180790-90-3(Hazardous Substances Data)

Upstream product

• 74-88-4 methyl iodide 

Relevant articles and documents

Potential antifungal agents. Synthesis and activity of 2-alkylthiopyridine-4-carbothioamides

A series of 2-alkylthiopyridine-4-carbothioamides were synthesized, and their antifungal potency was tested. The chemical structures were proved by IR and 1H-NMR data and by elemental analysis. The MIC and MFC assessment were used for the estimation of potential activity in vitro. The study comprising 21 clinical isolates of fungi showed that compounds 5h and 5j exhibited fair inhibitory activity against some yeasts and dermatophytes. Selective fungistatic activity against dermatophytes (MIC = 3.12-25.0 μg/mL) was found also in compound 5g. None of the above compounds showed inhibitory activity against non-dermatophyte filamentous fungi. Microbiological activity of 2-alkylthiopyridine-4-carbothioamides appears to be mainly related to hydrophobicity of alkyl in position 2.