Potential antifungal agents. Synthesis and activity of 2-alkylthiopyridine-4-carbothioamides

Article abstract of DOI:10.1016/0223-5234(96)89165-3

A series of 2-alkylthiopyridine-4-carbothioamides were synthesized, and their antifungal potency was tested. The chemical structures were proved by IR and ¹H-NMR data and by elemental analysis. The MIC and MFC assessment were used for the estimation of potential activity in vitro. The study comprising 21 clinical isolates of fungi showed that compounds 5h and 5j exhibited fair inhibitory activity against some yeasts and dermatophytes. Selective fungistatic activity against dermatophytes (MIC = 3.12-25.0 μg/mL) was found also in compound 5g. None of the above compounds showed inhibitory activity against non-dermatophyte filamentous fungi. Microbiological activity of 2-alkylthiopyridine-4-carbothioamides appears to be mainly related to hydrophobicity of alkyl in position 2.