180794-89-2

Upstream product

• 188130-85-0 C₂₂H₃₀O₆ 
• 188130-84-9 C₂₈H₃₈O₆ 
• 824-94-2 p-methoxybenzyl chloride 
• 140148-49-8 (-)-3,4,5-tri-O-allyl-6-O-benzyl-myo-inositol 
• 100-39-0 benzyl bromide 
• 180794-88-1 (+)-3,4,5-tri-O-allyl-6-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 
• 181489-61-2 (-)-1,2:4,5-di-O-cyclohexylidene-3-O-allyl-myo-inositol 
• 145789-54-4 (-)-3,4,5-tri-O-allyl-6-O-benzyl-1,2-O-cyclohexylidene-myo-inositol 

Downstream Products

• 180794-91-6 (-)-2,6-di-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 3,4,5-tris(dibenzyl phosphate) 
• 160247-11-0 (-)-2,6-di-O-benzyl-myo-inositol 3,4,5-tris(dibenzyl phosphate) 
• 180794-90-5 (-)-2,6-di-O-benzyl-1-O-(p-methoxybenzyl)-myo-inositol 

Relevant academic research and scientific papers

A unified approach to unambiguous synthesis of the phosphatidylinositol-3-phosphates. Involved in intracellular signal transduction

A unified approach to unambiguous synthesis of the phosphatidylinositol-3-phosphates involved in intracellular signalling is illustrated by the synthesis of 1D-1-(1',2'- '-dihexadecanoyl-sn-glycero-3'-phospho)-myo-inositol-3,4,5-trisphosphate.

Synthesis of the D-3 series of phosphatidylinositol phosphates

The 3-mono-, 3,4-bis-, and 3,4,5-trisphosphates of L-α-phosphatidyl-D-myo-inositol have been synthesized in their optically active forms from the two enantiomers of 1,2:5,6-di-O-cyclohexylidene-myo-inositol. These chiral precursors were prepared by a facile biocatalytic resolution, in which the 4-butyryl ester of the racemic compound was subjected to enantioselective hydrolysis by porcine pancreatic lipase in a biphasic system. The overall yield from individual chiral precursors ranged from 32% for the 3,4,5-trisphosphate to 39% for the monophosphate.