180799-66-0Relevant academic research and scientific papers
Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain.
Peet,Kim,Marquart,Angelastro,Nieduzak,White,Friedrich,Flynn,Webster,Vaz,Linnik,Koehl,Mehdi,Bey,Emary,Hwang
, p. 2365 - 2370 (1999)
The synthesis of [1-[(5-hydroxy-4-(phenylmethyl)-3-oxazolidinyl)carbonyl]-2-ethylpropy lcarbamic acid phenylmethyl ester (2; MDL 104,903), a potent inhibitor of calpain, is described. Synthesis of related compounds, which offer insights into the mechanism of action for 2, are also described, as is an O-acetyl prodrug derivative of 2.
