Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain.

DOI: 10.1016/S0960-894X(99)00391-1

Source and publish data:

Bioorganic and medicinal chemistry letters p. 2365 - 2370 (1999)

Update date:2022-09-26

Topics:

Authors:

Peet Peet

Kim Kim

Marquart

Angelastro

Nieduzak

White White

Friedrich

Flynn Flynn

Webster Webster

Vaz Vaz

Linnik Linnik

Koehl Koehl

Mehdi Mehdi

Bey Bey

Emary Emary

Hwang Hwang

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Article abstract of DOI:10.1016/S0960-894X(99)00391-1

The synthesis of [1-[(5-hydroxy-4-(phenylmethyl)-3-oxazolidinyl)carbonyl]-2-ethylpropy lcarbamic acid phenylmethyl ester (2; MDL 104,903), a potent inhibitor of calpain, is described. Synthesis of related compounds, which offer insights into the mechanism of action for 2, are also described, as is an O-acetyl prodrug derivative of 2.

Full text of DOI:10.1016/S0960-894X(99)00391-1

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