Hydroxyoxazolidines as alpha-aminoacetaldehye equivalents: novel inhibitors of calpain.

DOI: 10.1016/S0960-894X(99)00391-1

Source and publish data:

Bioorganic and medicinal chemistry letters p. 2365 - 2370 (1999)

Update date:2022-09-26

Topics:

Authors:

Peet Peet

Kim Kim

Marquart

Angelastro

Nieduzak

White White

Friedrich

Flynn Flynn

Webster Webster

Vaz Vaz

Linnik Linnik

Koehl Koehl

Mehdi Mehdi

Bey Bey

Emary Emary

Hwang Hwang

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/S0960-894X(99)00391-1

The synthesis of [1-[(5-hydroxy-4-(phenylmethyl)-3-oxazolidinyl)carbonyl]-2-ethylpropy lcarbamic acid phenylmethyl ester (2; MDL 104,903), a potent inhibitor of calpain, is described. Synthesis of related compounds, which offer insights into the mechanism of action for 2, are also described, as is an O-acetyl prodrug derivative of 2.

Full text of DOI:10.1016/S0960-894X(99)00391-1

Products guided by the article

Product name:[(S)-1-((S)-4-Benzyl-5-oxo-oxazolidine-3-carbonyl)-2-methyl-propyl]-carbamic acid benzyl ester

Cas No:180799-66-0

R&D Labs maybe for 180799-66-0

Pengchen New Material Technology Co., Ltd.

Contact:+86-512-63680537

Address:99.6 km of national road 318, Meiyan Community,Pingwang Town, Wujiang District, Suzhou 215225
Shandong Yuanli Science and Technology Co., Ltd.

Contact:86-0536-6777557

Address:Zhuliu Industiral Park,Changle County
KA-SHING Business Trade Macau Co., Ltd.

Contact:00853-28430045

Address:23rd Floor, Block 3 La Cite, Areia Preta, Macao
HaiNan Periwinkle Pharmaceutical Co.,Ltd.

website:http://www.cchpharm.com/en/index.html

Contact:020-82208978

Address:Gongye road,Wuzhishan city,HaiNan province
Hangzhou Bayee Chemical Co.,Ltd.

Contact:+86-571-86990109

Address:No.380, Jiangnan Auenue, Binjiang District, Hangzhou, China

Relevant to this article

Doi:10.1021/ja01468a040
(1961)
Catecholborane bound to titanocene. Unusual coordination of ligand σ-bonds

Doi:10.1021/ja962086v
(1996)
Doi:10.1016/S0022-328X(97)00075-2
(1997)
Doi:10.1007/BF00474882
()
Photocatalytic Cyclization/Defluorination Domino Sequence to Access 3-Fluoro-1,5-dihydro-2 H-pyrrol-2-one Scaffold

Doi:10.1021/acs.orglett.1c01477
(2021)
Transannular Diels-Alder reaction studies with an activated dienophile. An enantioselective synthesis of an A.B.C.[6.6.6.] trans-syn-cis tricycle

Doi:10.1016/S0040-4020(97)00997-6
(1997)

Article Doi