Bioorganic and medicinal chemistry letters p. 2365 - 2370 (1999)
Update date:2022-09-26
Topics:
Peet
Kim
Marquart
Angelastro
Nieduzak
White
Friedrich
Flynn
Webster
Vaz
Linnik
Koehl
Mehdi
Bey
Emary
Hwang
The synthesis of [1-[(5-hydroxy-4-(phenylmethyl)-3-oxazolidinyl)carbonyl]-2-ethylpropy lcarbamic acid phenylmethyl ester (2; MDL 104,903), a potent inhibitor of calpain, is described. Synthesis of related compounds, which offer insights into the mechanism of action for 2, are also described, as is an O-acetyl prodrug derivative of 2.
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(1961)Doi:10.1021/ja962086v
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(2021)Doi:10.1016/S0040-4020(97)00997-6
(1997)
