1808-12-4 Usage
Description
Bromodiphenhydramine is a histamine H1 receptor antagonist. It induces histamine release in isolated guinea pig lung when used at a concentration of 1 mM but completely prevents ovalbumin-induced histamine release in lungs isolated from ovalbumin-sensitized guinea pigs when used at concentrations of 100 and 200 μg/ml. Bromodiphenhydramine (17 mg/kg) inhibits formalin-induced paw edema in rats. It increases survival in a mouse model of systemic S. typhimurium infection when administered at doses of 1.5 and 3 mg/kg.
Uses
Antihistaminic.
Definition
ChEBI: The hydrochloride salt of bromazine. An antihistamine with antimicrobial properties, it is used in the control of cutaneous allergies.
General Description
Bromodiphenhydraminehydrochloride, 2-[(4-bromophenyl)-phenylmethoxy]-N, N-dimethylethanamine hydrochloride(Ambodryl Hydrochloride), is a white to pale buff crystallinepowder that is freely soluble in water and in alcohol.Relative to diphenhydramine, bromodiphenhydramine ismore lipid soluble and was twice as effective in protectingagainst the lethal effects of histamine aerosols.
Check Digit Verification of cas no
The CAS Registry Mumber 1808-12-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,8,0 and 8 respectively; the second part has 2 digits, 1 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 1808-12:
(6*1)+(5*8)+(4*0)+(3*8)+(2*1)+(1*2)=74
74 % 10 = 4
So 1808-12-4 is a valid CAS Registry Number.
InChI:InChI=1/C17H20BrNO.ClH/c1-19(2)12-13-20-17(14-6-4-3-5-7-14)15-8-10-16(18)11-9-15;/h3-11,17H,12-13H2,1-2H3;1H
1808-12-4Relevant articles and documents
Anti-inflammatory effects of two new methyl and morpholine derivatives of diphenhydramine on rats
Ahmadi, Abbas,Khalili, Mohsen,Hajikhani, Ramin,Safari, Narjes,Nahri-Niknafs, Babak
, p. 3532 - 3540 (2013/02/25)
Diphenhydramines are one of the first-generation histamine H1-receptor antagonists of the ethanolamine class that demonstrate many pharmacological properties including anti-inflammatory effects. In this research, bromo (II) and two new tolyl derivatives of I, (Di [p-tolyl] [dimethylaminoethoxy] methane, III) and (Di [p-tolyl] [2-morpholinoethoxy] methane, IV) were synthesized. Their acute and chronic anti-inflammatory activities were evaluated with the formalin and histamine-induced rat paw edema. The vascular permeability in formalin and histamine-induced paw edema, in xylene-induced ear edema, and in peritonitis after acetic acid application into peritoneal cavity were also measured and compared to II. Cotton pellet-induced granuloma model was selected for inducing chronic inflammations in rats. The newly synthesized analogs of diphenhydramine seemed effective to decrease acute inflammations. It was concluded that the prominent anti-phlogistic effects of the new drugs could be related to its reduction vascular permeability mechanism(s) or to its antagonistic effects on H1 histamine receptors. Springer Science+Business Media, LLC 2011.
